Eric J Bennett
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Explore the profile of Eric J Bennett including associated specialties, affiliations and a list of published articles.
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64
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5237
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Recent Articles
1.
Ford P, Garshott D, Narasimhan M, Ge X, Jordahl E, Subramanya S, et al.
Cell Rep
. 2025 Mar;
44(3):115371.
PMID: 40022732
The initiation-specific ribosome-associated quality control pathway (iRQC) is activated when translation initiation complexes fail to transition to elongation-competent 80S ribosomes. Upon iRQC activation, RNF10 ubiquitylates the 40S proteins uS3 and...
2.
Ford P, Narasimhan M, Bennett E
Cell Rep
. 2024 Dec;
43(12):115050.
PMID: 39661518
Translation control mechanisms connect the largely static genome to the highly dynamic proteome. At each step in the translation cycle, multiple layers of regulation enable efficient protein biogenesis under optimal...
3.
Lam K, Kim Y, Ong C, Liu A, Zhou F, Sunshine M, et al.
bioRxiv
. 2024 Oct;
PMID: 39386464
Oncogenic growth places great strain and dependence on the proteostasis network. This has made proteostasis pathways attractive therapeutic targets in cancer, but efforts to drug these pathways have yielded disappointing...
4.
Ford P, Bennett E
Cell Rep
. 2023 Nov;
42(11):113278.
PMID: 37910507
Using small molecules that trap translation factors within translating ribosomes, Gurzeler et al. and Oltion et al. identify a new branch of the ribosome-associated quality-control (RQC) pathway. This mode of...
5.
Monda J, Ge X, Hunkeler M, Donovan K, Ma M, Jin C, et al.
Cell Rep
. 2023 May;
42(5):112496.
PMID: 37167062
HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 engages its structurally diverse substrates and how...
6.
Nan Q, Liang H, Mendoza J, Liu L, Fulzele A, Wright A, et al.
Plant Cell
. 2023 Apr;
35(7):2678-2693.
PMID: 37017144
Formative asymmetric divisions produce cells with different fates and are critical for development. We show the maize (Zea mays) myosin XI protein, OPAQUE1 (O1), is necessary for asymmetric divisions during...
7.
Chua B, Lennan C, Sunshine M, Dreifke D, Chawla A, Bennett E, et al.
Cell Stem Cell
. 2023 Mar;
30(4):460-472.e6.
PMID: 36948186
Hematopoietic stem cells (HSCs) regenerate blood cells throughout life. To preserve their fitness, HSCs are particularly dependent on maintaining protein homeostasis (proteostasis). However, how HSCs purge misfolded proteins is unknown....
8.
Bhaduri S, Aguayo A, Ohno Y, Proietto M, Jung J, Wang I, et al.
EMBO J
. 2022 Nov;
42(4):e112275.
PMID: 36350249
Nearly one-third of nascent proteins are initially targeted to the endoplasmic reticulum (ER), where they are correctly folded and assembled before being delivered to their final cellular destinations. To prevent...
9.
Nan Q, Char S, Bennett E, Yang B, Facette M
Plant Cell
. 2022 Oct;
35(1):469-487.
PMID: 36227066
Polarization of cells prior to asymmetric cell division is crucial for correct cell divisions, cell fate, and tissue patterning. In maize (Zea mays) stomatal development, the polarization of subsidiary mother...
10.
Banta K, Xu X, Chitre A, Au-Yeung A, Takahashi C, OGorman W, et al.
Immunity
. 2022 Mar;
55(3):512-526.e9.
PMID: 35263569
Dual blockade of the PD-1 and TIGIT coinhibitory receptors on T cells shows promising early results in cancer patients. Here, we studied the mechanisms whereby PD-1 and/or TIGIT blockade modulate...