Raymond M Paranal
Overview
Explore the profile of Raymond M Paranal including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
157
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0
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Recent Articles
1.
Paranal R, Wood L, Klein A, Roberts N
Fam Cancer
. 2024 Apr;
23(4):419-428.
PMID: 38609521
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that is the result of an accumulation of sequential genetic alterations. These genetic alterations can either be inherited, such as pathogenic germline...
2.
Paranal R, Jiang Z, Hutchings D, Kryklyva V, Gauthier C, Fujikura K, et al.
J Pathol
. 2023 Jun;
260(4):455-464.
PMID: 37345735
Understanding the timing and spectrum of genetic alterations that contribute to the development of pancreatic cancer is essential for effective interventions and treatments. The aim of this study was to...
3.
Kimura H, Paranal R, Nanda N, Wood L, Eshleman J, Hruban R, et al.
Elife
. 2022 Jan;
11.
PMID: 35001868
Pathogenic germline variants are associated with an increased risk of pancreatic ductal adenocarcinoma (PDAC). variants of uncertain significance (VUSs) are reported in up to 4.3% of patients with PDAC and...
4.
Eser P, Paranal R, Son J, Ivanova E, Kuang Y, Haikala H, et al.
Sci Transl Med
. 2021 Sep;
13(609):eabb3738.
PMID: 34516823
The clinical efficacy of epidermal growth factor receptor (EGFR)–targeted therapy in -mutant non–small cell lung cancer is limited by the development of drug resistance. One mechanism of EGFR inhibitor resistance...
5.
Zeng M, Lu J, Li L, Feru F, Quan C, Gero T, et al.
Cell Chem Biol
. 2017 Aug;
24(8):1005-1016.e3.
PMID: 28781124
Targeted covalent small molecules have shown promise for cancers driven by KRAS G12C. Allosteric compounds that access an inducible pocket formed by movement of a dynamic structural element in KRAS,...
6.
Kosaka T, Tanizaki J, Paranal R, Endoh H, Lydon C, Capelletti M, et al.
Cancer Res
. 2017 Apr;
77(10):2712-2721.
PMID: 28363995
Insertion mutations in EGFR and HER2 both occur at analogous positions in exon 20. Non-small cell lung cancer (NSCLC) patients with tumors harboring these mutations seldom achieve clinical responses to...
7.
Mowafy S, Galanis A, Doctor Z, Paranal R, Lasheen D, Farag N, et al.
Bioorg Med Chem
. 2016 Jun;
24(16):3501-12.
PMID: 27288180
A new series of 4-anilinoquinazolines with C-6 ureido and thioureido side chains and various substituents at the C-4 anilino moiety was designed, synthesized and evaluated as wild type (WT) and...