Understanding Familial Risk of Pancreatic Ductal Adenocarcinoma

Overview

Journal Fam Cancer

Publisher Springer

Specialty Oncology

Date 2024 Apr 12

PMID 38609521

Authors

Raymond M Paranal

Laura D Wood

Alison P Klein

Nicholas J Roberts

Affiliations

Soon will be listed here.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that is the result of an accumulation of sequential genetic alterations. These genetic alterations can either be inherited, such as pathogenic germline variants that are associated with an increased risk of cancer, or acquired, such as somatic mutations that occur during the lifetime of an individual. Understanding the genetic basis of inherited risk of PDAC is essential to advancing patient care and outcomes through improved clinical surveillance, early detection initiatives, and targeted therapies. In this review we discuss factors associated with an increased risk of PDAC, the prevalence of genetic variants associated with an increased risk in patients with PDAC, estimates of PDAC risk in carriers of pathogenic germline variants in genes associated with an increased risk of PDAC. The role of common variants in pancreatic cancer risk will also be discussed.

References

Siegel R, Miller K, Wagle N, Jemal A . Cancer statistics, 2023. CA Cancer J Clin. 2023; 73(1):17-48. DOI: 10.3322/caac.21763. View

Rahib L, Wehner M, Matrisian L, Nead K . Estimated Projection of US Cancer Incidence and Death to 2040. JAMA Netw Open. 2021; 4(4):e214708. PMC: 8027914. DOI: 10.1001/jamanetworkopen.2021.4708. View

Vincent A, Herman J, Schulick R, Hruban R, Goggins M . Pancreatic cancer. Lancet. 2011; 378(9791):607-20. PMC: 3062508. DOI: 10.1016/S0140-6736(10)62307-0. View

Permuth-Wey J, Egan K . Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis. Fam Cancer. 2008; 8(2):109-17. DOI: 10.1007/s10689-008-9214-8. View

Klein A . Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors. Nat Rev Gastroenterol Hepatol. 2021; 18(7):493-502. PMC: 9265847. DOI: 10.1038/s41575-021-00457-x. View

Hamada T, Yuan C, Yurgelun M, Perez K, Khalaf N, Morales-Oyarvide V . Family history of cancer, Ashkenazi Jewish ancestry, and pancreatic cancer risk. Br J Cancer. 2019; 120(8):848-854. PMC: 6474278. DOI: 10.1038/s41416-019-0426-5. View

Lichtenstein P, Holm N, Verkasalo P, Iliadou A, Kaprio J, Koskenvuo M . Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000; 343(2):78-85. DOI: 10.1056/NEJM200007133430201. View

Porter N, Laheru D, Lau B, He J, Zheng L, Narang A . Risk of Pancreatic Cancer in the Long-Term Prospective Follow-Up of Familial Pancreatic Cancer Kindreds. J Natl Cancer Inst. 2022; 114(12):1681-1688. PMC: 9745433. DOI: 10.1093/jnci/djac167. View

Michaud D, Giovannucci E, Willett W, Colditz G, Stampfer M, Fuchs C . Physical activity, obesity, height, and the risk of pancreatic cancer. JAMA. 2001; 286(8):921-9. DOI: 10.1001/jama.286.8.921. View

10.

Jacobs E, Chanock S, Fuchs C, Lacroix A, McWilliams R, Steplowski E . Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Int J Cancer. 2010; 127(6):1421-8. PMC: 2926939. DOI: 10.1002/ijc.25148. View

11.

Stolzenberg-Solomon R, Schairer C, Moore S, Hollenbeck A, Silverman D . Lifetime adiposity and risk of pancreatic cancer in the NIH-AARP Diet and Health Study cohort. Am J Clin Nutr. 2013; 98(4):1057-65. PMC: 3778860. DOI: 10.3945/ajcn.113.058123. View

12.

Iodice S, Gandini S, Maisonneuve P, Lowenfels A . Tobacco and the risk of pancreatic cancer: a review and meta-analysis. Langenbecks Arch Surg. 2008; 393(4):535-45. DOI: 10.1007/s00423-007-0266-2. View

13.

Bosetti C, Lucenteforte E, Silverman D, Petersen G, Bracci P, Ji B . Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4). Ann Oncol. 2011; 23(7):1880-8. PMC: 3387822. DOI: 10.1093/annonc/mdr541. View

14.

Koyanagi Y, Ito H, Matsuo K, Sugawara Y, Hidaka A, Sawada N . Smoking and Pancreatic Cancer Incidence: A Pooled Analysis of 10 Population-Based Cohort Studies in Japan. Cancer Epidemiol Biomarkers Prev. 2019; 28(8):1370-1378. DOI: 10.1158/1055-9965.EPI-18-1327. View

15.

Lucenteforte E, La Vecchia C, Silverman D, Petersen G, Bracci P, Ji B . Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol. 2011; 23(2):374-82. PMC: 3265544. DOI: 10.1093/annonc/mdr120. View

16.

Chari S, Leibson C, Rabe K, Ransom J, de Andrade M, Petersen G . Probability of pancreatic cancer following diabetes: a population-based study. Gastroenterology. 2005; 129(2):504-11. PMC: 2377196. DOI: 10.1016/j.gastro.2005.05.007. View

17.

Gupta S, Vittinghoff E, Bertenthal D, Corley D, Shen H, Walter L . New-onset diabetes and pancreatic cancer. Clin Gastroenterol Hepatol. 2006; 4(11):1366-72. DOI: 10.1016/j.cgh.2006.06.024. View

18.

Munigala S, Singh A, Gelrud A, Agarwal B . Predictors for Pancreatic Cancer Diagnosis Following New-Onset Diabetes Mellitus. Clin Transl Gastroenterol. 2015; 6:e118. PMC: 4816040. DOI: 10.1038/ctg.2015.44. View

19.

Everhart J, Wright D . Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA. 1995; 273(20):1605-9. View

20.

Huxley R, Ansary-Moghaddam A, Berrington de Gonzalez A, Barzi F, Woodward M . Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer. 2005; 92(11):2076-83. PMC: 2361795. DOI: 10.1038/sj.bjc.6602619. View