Ray Rosa
Overview
Explore the profile of Ray Rosa including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
288
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0
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Recent Articles
1.
Bojic L, McLaren D, Harms A, Hankemeier T, Dane A, Wang S, et al.
Anal Bioanal Chem
. 2015 Oct;
408(1):97-105.
PMID: 26511226
Oxylipins are oxidation products of polyunsaturated fatty acids (PUFAs) that affect a broad range of physiological processes, including cell proliferation, inflammation, inflammation resolution, and vascular function. Moreover, oxylipins are readily...
2.
Zhang L, McCabe T, Condra J, Ni Y, Peterson L, Wang W, et al.
Int J Biol Sci
. 2012 Feb;
8(3):310-27.
PMID: 22355267
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with sub-nanomolar affinity and...
3.
Han S, Flattery A, McLaren D, Raubertas R, Lee S, Mendoza V, et al.
J Cardiovasc Transl Res
. 2011 Dec;
5(1):75-83.
PMID: 22194019
To assess cardiovascular risk in both clinical and basic research settings, it is imperative to be able to accurately measure plasma lipid levels. Here, methods commonly used to measure lipoproteins...
4.
Yin W, Carballo-Jane E, McLaren D, Mendoza V, Gagen K, Geoghagen N, et al.
J Lipid Res
. 2011 Oct;
53(1):51-65.
PMID: 22021650
In an attempt to understand the applicability of various animal models to dyslipidemia in humans and to identify improved preclinical models for target discovery and validation for dyslipidemia, we measured...
5.
Chen Z, Wang S, Krsmanovic M, Castro-Perez J, Gagen K, Mendoza V, et al.
Metabolism
. 2011 Oct;
61(4):470-81.
PMID: 22001333
The objective was to assess whether pharmacological activation of lecithin cholesterol acyltransferase (LCAT) could exert beneficial effects on lipoprotein metabolism. A putative small molecule activator (compound A) was used as...
6.
Smith C, Ali A, Hammond M, Li H, Lu Z, Napolitano J, et al.
J Med Chem
. 2011 Jun;
54(13):4880-95.
PMID: 21682257
The development of the structure-activity studies leading to the discovery of anacetrapib is described. These studies focused on varying the substitution of the oxazolidinone ring of the 5-aryloxazolidinone system. Specifically,...
7.
Ni Y, Di Marco S, Condra J, Peterson L, Wang W, Wang F, et al.
J Lipid Res
. 2010 Oct;
52(1):78-86.
PMID: 20959675
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We have identified a fragment antigen-binding (Fab) 1D05 which binds PCSK9 with...
8.
Yang X, Peterson L, Thieringer R, Deignan J, Wang X, Zhu J, et al.
J Clin Invest
. 2010 Jun;
120(7):2414-22.
PMID: 20577049
Atherosclerosis represents the most significant risk factor for coronary artery disease (CAD), the leading cause of death in developed countries. To better understand the pathogenesis of atherosclerosis, we applied a...