Lyndon J Mitnaul
Overview
Explore the profile of Lyndon J Mitnaul including associated specialties, affiliations and a list of published articles.
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16
Citations
1080
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Recent Articles
1.
Sun B, Chiou J, Traylor M, Benner C, Hsu Y, Richardson T, et al.
Nature
. 2023 Oct;
622(7982):329-338.
PMID: 37794186
The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a detailed summary of this initiative, including technical...
2.
Szustakowski J, Balasubramanian S, Kvikstad E, Khalid S, Bronson P, Sasson A, et al.
Nat Genet
. 2021 Jun;
53(7):942-948.
PMID: 34183854
The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private-public partnership between the UK Biobank (UKB) and eight biopharmaceutical companies that will complete the sequencing of exomes for all ~500,000...
3.
Dewey F, Murray M, Overton J, Habegger L, Leader J, Fetterolf S, et al.
Science
. 2016 Dec;
354(6319).
PMID: 28008009
The DiscovEHR collaboration between the Regeneron Genetics Center and Geisinger Health System couples high-throughput sequencing to an integrated health care system using longitudinal electronic health records (EHRs). We sequenced the...
4.
Singaraja R, Sivapalaratnam S, Hovingh K, Dube M, Castro-Perez J, Collins H, et al.
Circ Cardiovasc Genet
. 2012 Dec;
6(1):54-62.
PMID: 23243195
Background: Endothelial lipase is a phospholipase with activity against high-density lipoprotein. Although a small number of mutations in LIPG have been described, the role of LIPG in protection against atherosclerosis...
5.
Zhang L, McCabe T, Condra J, Ni Y, Peterson L, Wang W, et al.
Int J Biol Sci
. 2012 Feb;
8(3):310-27.
PMID: 22355267
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with sub-nanomolar affinity and...
6.
Yin W, Carballo-Jane E, McLaren D, Mendoza V, Gagen K, Geoghagen N, et al.
J Lipid Res
. 2011 Oct;
53(1):51-65.
PMID: 22021650
In an attempt to understand the applicability of various animal models to dyslipidemia in humans and to identify improved preclinical models for target discovery and validation for dyslipidemia, we measured...
7.
Ason B, Castro-Perez J, Tep S, Stefanni A, Tadin-Strapps M, Roddy T, et al.
Lipids
. 2011 Aug;
46(11):991-1003.
PMID: 21826528
The association between hypercholesterolemia and elevated serum apolipoprotein B (APOB) has generated interest in APOB as a therapeutic target for patients at risk of developing cardiovascular disease. In the clinic,...
8.
Tadin-Strapps M, Peterson L, Cumiskey A, Rosa R, Mendoza V, Castro-Perez J, et al.
J Lipid Res
. 2011 Mar;
52(6):1084-1097.
PMID: 21398511
Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE⁻/⁻ and low density lipoprotein receptor (LDLr)⁻/⁻ mice have been extensively used for...
9.
Ni Y, Di Marco S, Condra J, Peterson L, Wang W, Wang F, et al.
J Lipid Res
. 2010 Oct;
52(1):78-86.
PMID: 20959675
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We have identified a fragment antigen-binding (Fab) 1D05 which binds PCSK9 with...
10.
Tu Z, Argmann C, Wong K, Mitnaul L, Edwards S, Sach I, et al.
Genome Res
. 2009 Mar;
19(6):1057-67.
PMID: 19261841
Insulin resistance is one of the dominant symptoms of type 2 diabetes (T2D). Although the molecular mechanisms leading to this resistance are largely unknown, experimental data support that the insulin...