Brian K Hubbard
Overview
Explore the profile of Brian K Hubbard including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
47
Citations
1277
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Johnson E, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, et al.
Nature
. 2019 Jun;
571(7763):72-78.
PMID: 31217586
New antibiotics are needed to combat rising levels of resistance, with new Mycobacterium tuberculosis (Mtb) drugs having the highest priority. However, conventional whole-cell and biochemical antibiotic screens have failed. Here...
2.
Fang C, Lee K, Nietupski R, Bates R, Fernandez-Menendez R, Lopez-Roman E, et al.
Bioorg Med Chem Lett
. 2018 Oct;
28(22):3529-3533.
PMID: 30316633
Previous work established a coumarin scaffold as a starting point for inhibition of Mycobacterium tuberculosis (Mtb) FadD32 enzymatic activity. After further profiling of the coumarin inhibitor 4 revealed chemical instability,...
3.
Nakajima K, Chatelain R, Clairmont K, Commerford R, Coppola G, Daniels T, et al.
J Med Chem
. 2017 May;
60(11):4657-4664.
PMID: 28498655
Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes to 1 include bioisosteric replacement of the amide...
4.
Garvie C, Fraley C, Elowe N, Culyba E, Lemke C, Hubbard B, et al.
Protein Sci
. 2016 Aug;
25(11):2018-2027.
PMID: 27534510
Circulating low-density lipoprotein cholesterol (LDLc) is regulated by membrane-bound LDL receptor (LDLr). Upon LDLc and LDLr interaction the complex is internalized by the cell, leading to LDLc degradation and LDLr...
5.
Imbriglio J, Shen D, Liang R, Marby K, You M, Youm H, et al.
J Med Chem
. 2015 Nov;
58(23):9345-53.
PMID: 26561979
DGAT2 plays a critical role in hepatic triglyceride production, and data suggests that inhibition of DGAT2 could prove to be beneficial in treating a number of disease states. This article...
6.
Previs S, Herath K, Castro-Perez J, Mahsut A, Zhou H, McLaren D, et al.
Methods Enzymol
. 2015 Sep;
561:331-58.
PMID: 26358910
Stable isotope tracers are widely used to quantify metabolic rates, and yet a limited number of studies have considered the impact of analytical error on estimates of flux. For example,...
7.
Clifton M, Dranow D, Leed A, Fulroth B, Fairman J, Abendroth J, et al.
PLoS One
. 2015 Apr;
10(4):e0125010.
PMID: 25909780
Crystallization of a maltose-binding protein MCL1 fusion has yielded a robust crystallography platform that generated the first apo MCL1 crystal structure, as well as five ligand-bound structures. The ability to...
8.
Fang C, DSouza B, Thompson C, Clifton M, Fairman J, Fulroth B, et al.
ACS Med Chem Lett
. 2014 Dec;
5(12):1308-12.
PMID: 25516789
A direct binding screen of 100 000 sp(3)-rich molecules identified a single diastereomer of a macrolactam core that binds specifically to myeloid cell leukemia 1 (MCL1). A comprehensive toolbox of...
9.
Serrano-Wu M, Coppola G, Gong Y, Neubert A, Chatelain R, Clairmont K, et al.
ACS Med Chem Lett
. 2014 Jun;
3(5):411-5.
PMID: 24900485
High DGAT1 expression levels in the small intestine highlight the critical role this enzyme plays in nutrient absorption. Identification of inhibitors which predominantly inhibit DGAT1 in the gut is an...
10.
Herath K, Zhong W, Yang J, Mahsut A, Rohm R, Shah V, et al.
Rapid Commun Mass Spectrom
. 2013 Dec;
28(3):239-44.
PMID: 24375874
Rationale: The ability to measure low levels of (2)H-labeling is important in studies of metabolic flux, e.g. one can estimate lipid synthesis by administering (2)H2O and then measuring the incorporation...