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Rashna Bhandari

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Articles 35
Citations 884
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Recent Articles
11.
Lolla P, Shah A, Unnikannan C, Oddi V, Bhandari R
Biochem J . 2021 Apr; 478(8):1647-1661. PMID: 33821962
The transcription factor MYC regulates cell survival and growth, and its level is tightly controlled in normal cells. We report that serine pyrophosphorylation - a posttranslational modification triggered by inositol...
12.
Shah A, Ganguli S, Sen J, Bhandari R
J Indian Inst Sci . 2020 Mar; 97(1):23-40. PMID: 32214696
Inositol pyrophosphates (PP-IPs) are a class of energy-rich signalling molecules found in all eukaryotic cells. These are derivatives of inositol that contain one or more diphosphate (or pyrophosphate) groups in...
13.
Chanduri M, Bhandari R
Methods Mol Biol . 2019 Nov; 2091:93-105. PMID: 31773573
Protein pyrophosphorylation involves the transfer of a high-energy β-phosphate from inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (InsP) to phosphorylated serine residues. Over a decade of research has established several proteins,...
14.
Ganguli S, Shah A, Hamid A, Singh A, Palakurti R, Bhandari R
Adv Biol Regul . 2019 Nov; 75():100662. PMID: 31668836
Inositol pyrophosphates (PP-IPs) are a class of energy rich metabolites present in all eukaryotic cells. The hydroxyl groups on these water soluble derivatives of inositol are substituted with diphosphate and...
15.
Deota S, Rathnachalam S, Namrata K, Boob M, Fulzele A, Radhika S, et al.
J Mol Biol . 2019 Apr; 431(11):2127-2142. PMID: 30974121
Cyclin-dependent kinase 1 (CDK1) is essential for cell-cycle progression. While dependence of CDK activity on cyclin levels is well established, molecular mechanisms that regulate their binding are less understood. Here,...
16.
Singh J, Steck N, De D, Hofer A, Ripp A, Captain I, et al.
Angew Chem Int Ed Engl . 2019 Jan; 58(12):3928-3933. PMID: 30681761
An iterative polyphosphorylation approach is described, which is based on a phosphoramidite (P-amidite) derived reagent (c-PyPA) obtained from the cyclization of pyrophosphate with a reactive diisopropylaminodichlorophosphine. This type of reagent...
17.
Ansari M, Kumar A, Ahari D, Priyadarshi A, Lolla P, Bhandari R, et al.
Faraday Discuss . 2018 Jan; 207(0):91-113. PMID: 29362761
Protein Charge Transfer Spectra (ProCharTS) originate when charged amino/carboxylate groups in the side chains of Lys/Glu act as electronic charge acceptors/donors for photoinduced charge transfer either from/to the polypeptide backbone...
18.
Malla A, Bhandari R
J Cell Sci . 2017 Jul; 130(17):2854-2866. PMID: 28743739
Inositol hexakisphosphate kinases (IP6Ks) are enzymes that synthesise the inositol pyrophosphate 5-diphosphoinositol pentakisphosphate (5-IP), which is known to regulate several physiological processes. Deletion of IP6K1, but not other IP6K isoforms,...
19.
Chanduri M, Rai A, Malla A, Wu M, Fiedler D, Mallik R, et al.
Biochem J . 2016 Jul; 473(19):3031-47. PMID: 27474409
Inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (IP7), are conserved eukaryotic signaling molecules that possess pyrophosphate and monophosphate moieties. Generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein...
20.
Jadav R, Kumar D, Buwa N, Ganguli S, Thampatty S, Balasubramanian N, et al.
Cell Signal . 2016 May; 28(8):1124-36. PMID: 27140681
Inositol hexakisphosphate kinases (IP6Ks), a family of enzymes found in all eukaryotes, are responsible for the synthesis of 5-diphosphoinositol pentakisphosphate (5-IP7) from inositol hexakisphosphate (IP6). Three isoforms of IP6Ks are...