Lena Gerwick
Overview
Explore the profile of Lena Gerwick including associated specialties, affiliations and a list of published articles.
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Articles
69
Citations
3493
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Recent Articles
1.
Rankin M, Khare D, Gerwick L, Sherman D, Gerwick W, Smith J
Structure
. 2025 Mar;
PMID: 40086440
Bacteria are rich sources of pharmaceutically valuable natural products, many crafted by modular polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). PKS and NRPS systems typically contain a thioesterase (TE)...
2.
Alexander K, Naman C, Iwasaki A, Mangoni A, Leao T, Reher R, et al.
J Nat Prod
. 2025 Jan;
88(2):322-335.
PMID: 39879528
A structurally novel metabolite, fatuamide A (), was discovered from a laboratory cultured strain of the marine cyanobacterium sp., collected from Faga'itua Bay, American Samoa. A bioassay-guided approach using NCI-H460...
3.
Ngo T, Ecker A, Ryu B, Guild A, Remmel A, Boudreau P, et al.
ACS Chem Biol
. 2024 Nov;
19(12):2593.
PMID: 39591979
No abstract available.
4.
Rankin M, Khare D, Gerwick L, Sherman D, Gerwick W, Smith J
bioRxiv
. 2024 Nov;
PMID: 39554124
Bacteria are rich sources of pharmaceutically valuable natural products, many crafted by modular polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). PKS and NRPS systems typically contain a thioesterase (TE)...
5.
Avalon N, Reis M, Thornburg C, Williamson R, Petras D, Aron A, et al.
J Am Chem Soc
. 2024 Jun;
146(27):18626-18638.
PMID: 38918178
Metals are important cofactors in the metabolic processes of cyanobacteria, including photosynthesis, cellular respiration, DNA replication, and the biosynthesis of primary and secondary metabolites. In adaptation to the marine environment,...
6.
Ngo T, Ecker A, Ryu B, Guild A, Remmel A, Boudreau P, et al.
ACS Chem Biol
. 2024 Feb;
19(3):619-628.
PMID: 38330248
The tropical marine cyanobacterium JHB is a prolific source of secondary metabolites with potential biomedical utility. Previous studies on this strain led to the discovery of several novel compounds such...
7.
Ngo T, Ecker A, Guild A, Remmel A, Boudreau P, Alexander K, et al.
bioRxiv
. 2023 Jul;
PMID: 37461655
The tropical marine cyanobacterium JHB is a prolific source of secondary metabolites with potential biomedical utility. Previous studies of this strain led to the discovery of several novel compounds such...
8.
Leao T, Wang M, da Silva R, Gurevich A, Bauermeister A, Gomes P, et al.
PNAS Nexus
. 2023 Jan;
1(5):pgac257.
PMID: 36712343
Microbial specialized metabolites are an important source of and inspiration for many pharmaceuticals, biotechnological products and play key roles in ecological processes. Untargeted metabolomics using liquid chromatography coupled with tandem...
9.
Taton A, Rohrer S, Diaz B, Reher R, Caraballo Rodriguez A, Pierce M, et al.
ACS Chem Biol
. 2022 Jun;
17(7):1910-1923.
PMID: 35761435
Columbamides are chlorinated acyl amide natural products, several of which exhibit cannabinomimetic activity. These compounds were originally discovered from a culture of the filamentous marine cyanobacterium PNG5-198 collected from the...
10.
Demirkiran O, Almaliti J, Leao T, Navarro G, Byrum T, Valeriote F, et al.
J Nat Prod
. 2021 Jul;
84(8):2081-2093.
PMID: 34269583
Three new compounds, portobelamides A and B ( and ), 3-amino-2-methyl-7-octynoic acid (AMOYA) and hydroxyisovaleric acid (Hiva) containing cyclic depsipeptides, and one long chain lipopeptide caciqueamide (), were isolated from...