Ralf Paul
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Explore the profile of Ralf Paul including associated specialties, affiliations and a list of published articles.
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11
Citations
1124
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Recent Articles
1.
Kalliokoski T, Kettunen H, Kumpulainen E, Kettunen E, Thieulin-Pardo G, Neumann L, et al.
Bioorg Med Chem Lett
. 2023 Aug;
94:129450.
PMID: 37591318
Methionine adenosyltransferase 2A (MAT2A) has been indicated as a drug target for oncology indications. Clinical trials with MAT2A inhibitors are currently on-going. Here, a structure-based virtual screening campaign was performed...
2.
Engstrom O, Belda O, Kullman-Magnusson M, Rapp M, Bohm K, Paul R, et al.
Bioorg Med Chem Lett
. 2020 Aug;
30(20):127471.
PMID: 32781219
Ubiquitin specific protease-7 (USP7) is considered an attractive target for cancer therapy by promoting degradation of the tumor suppressor p53 and negatively affecting the immune response to tumors. However, the...
3.
Zaremba-Czogalla M, Stumpp C, Bonifacio E, Paul R
Protein Expr Purif
. 2015 Feb;
110:65-71.
PMID: 25703052
The large scale screening of cytokine mutants is a component of binding and activity mapping and requires an efficient method of cytokine protein expression. Here, we compared recombinant IL-7 expression...
4.
Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi E, et al.
Cell
. 2008 May;
133(3):452-61.
PMID: 18455986
The two-component phosphorylation network is of critical importance for bacterial growth and physiology. Here, we address plasticity and interconnection of distinct signal transduction pathways within this network. In Caulobacter crescentus...
5.
Wassmann P, Chan C, Paul R, Beck A, Heerklotz H, Jenal U, et al.
Structure
. 2007 Aug;
15(8):915-27.
PMID: 17697997
Cyclic di-guanosine monophosphate (c-di-GMP) is a ubiquitous bacterial second messenger involved in the regulation of cell surface-associated traits and persistence. We have determined the crystal structure of PleD from Caulobacter...
6.
Paul R, Abel S, Wassmann P, Beck A, Heerklotz H, Jenal U
J Biol Chem
. 2007 Jul;
282(40):29170-7.
PMID: 17640875
Diguanylate cyclases (DGCs) are key enzymes of second messenger signaling in bacteria. Their activity is responsible for the condensation of two GTP molecules into the signaling compound cyclic di-GMP. Despite...
7.
Christen B, Christen M, Paul R, Schmid F, Folcher M, Jenoe P, et al.
J Biol Chem
. 2006 Aug;
281(42):32015-24.
PMID: 16923812
Cyclic di-guanosine monophosphate is a bacterial second messenger that has been implicated in biofilm formation, antibiotic resistance, and persistence of pathogenic bacteria in their animal host. Although the enzymes responsible...
8.
Chan C, Paul R, Samoray D, Amiot N, Giese B, Jenal U, et al.
Proc Natl Acad Sci U S A
. 2004 Dec;
101(49):17084-9.
PMID: 15569936
Recent discoveries suggest that a novel second messenger, bis-(3'-->5')-cyclic di-GMP (c-diGMP), is extensively used by bacteria to control multicellular behavior. Condensation of two GTP to the dinucleotide is catalyzed by...
9.
Paul R, Weiser S, Amiot N, Chan C, Schirmer T, Giese B, et al.
Genes Dev
. 2004 Apr;
18(6):715-27.
PMID: 15075296
Pole development is coordinated with the Caulobacter crescentus cell cycle by two-component signaling proteins. We show that an unusual response regulator, PleD, is required for polar differentiation and is sequestered...
10.
Aldridge P, Paul R, Goymer P, Rainey P, Jenal U
Mol Microbiol
. 2003 Mar;
47(6):1695-708.
PMID: 12622822
Several members of the two-component signal transduction family have been implicated in the control of polar development in Caulobacter crescentus: PleC and DivJ, two polarly localized histidine sensor kinases; and...