Rajeev K Mehlotra
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Explore the profile of Rajeev K Mehlotra including associated specialties, affiliations and a list of published articles.
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34
Citations
573
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Recent Articles
21.
Mehlotra R, Gray L, Blood-Zikursh M, Kloos Z, Henry-Halldin C, Tisch D, et al.
Am J Trop Med Hyg
. 2010 Jun;
82(6):1030-3.
PMID: 20519596
Four major malaria-causing Plasmodium spp. and lymphatic filariasis-causing Wuchereria bancrofti are co-endemic in many tropical and sub-tropical regions. Among molecular diagnostic assays, multiplex polymerase chain reaction (PCR)-based assays for the...
22.
Schoepflin S, Lin E, Kiniboro B, DaRe J, Mehlotra R, Zimmerman P, et al.
Am J Trop Med Hyg
. 2010 Mar;
82(4):529-34.
PMID: 20348494
A recent drug efficacy trial reported Coartem (artemether-lumefantrine) to be highly effective against Plasmodium falciparum in children less than 5 years of age in Papua New Guinea (PNG). In contrast,...
23.
Benish R, Rodriguez B, Zimmerman P, Mehlotra R
Infect Genet Evol
. 2009 Oct;
10(1):60-7.
PMID: 19819348
Human P-glycoprotein (P-gp), encoded by MDR1 (ABCB1), is an efflux transporter with a wide specificity for substrates/drugs, including HIV protease inhibitors which are commonly used in HIV/AIDS treatment. Three single...
24.
Belanger A, Caron P, Harvey M, Zimmerman P, Mehlotra R, Guillemette C
Drug Metab Dispos
. 2009 Jun;
37(9):1793-6.
PMID: 19487252
The non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) is directly conjugated by the UDP-glucuronosyltransferase (UGT) pathway to form EFV-N-glucuronide (EFV-G), but the enzyme(s) involved has not yet been identified. The glucuronidation...
25.
Mehlotra R, Henry-Halldin C, Zimmerman P
Pharmacogenomics
. 2009 Mar;
10(3):435-49.
PMID: 19290792
Drug resistance in malaria jeopardizes the most elementary objectives of malaria control--reducing suffering and eliminating mortality. An important, and so far the only known, mechanism of drug resistance appears to...
26.
Mehlotra R, Mattera G, Bockarie M, Maguire J, Baird J, Sharma Y, et al.
Antimicrob Agents Chemother
. 2008 Apr;
52(6):2212-22.
PMID: 18411325
Mutations in the chloroquine resistance (CQR) transporter gene of Plasmodium falciparum (Pfcrt; chromosome 7) play a key role in CQR, while mutations in the multidrug resistance gene (Pfmdr1; chromosome 5)...
27.
Mehlotra R, Bockarie M, Zimmerman P
Br J Clin Pharmacol
. 2007 Mar;
64(3):391-5.
PMID: 17391322
Aims: To determine the prevalence of the novel CYP2B6 functional polymorphism 983T>C in Papua New Guinea where HIV/AIDS poses a significant health problem. Method: We genotyped Papua New Guineans (PNG,...
28.
DaRe J, Mehlotra R, Michon P, Mueller I, Reeder J, Sharma Y, et al.
Malar J
. 2007 Mar;
6:34.
PMID: 17376240
Background: Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76. Previous...
29.
Mehlotra R, Bockarie M, Zimmerman P
Eur J Clin Pharmacol
. 2006 Nov;
63(1):1-8.
PMID: 17115150
Objective: UDP-glucuronosyltransferases (UGTs) UGT1A9 and UGT2B7 are involved in the metabolism of antimalarial dihydroartemisinin and antiretroviral zidovudine. Our aim was to analyze the prevalence of UGT1A9 (chromosome 2) and UGT2B7...
30.
Mehlotra R, Ziats M, Bockarie M, Zimmerman P
Eur J Clin Pharmacol
. 2006 Mar;
62(4):267-75.
PMID: 16506047
Objective: Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of artemisinin drugs, a novel series of antimalarials. Our aim was to analyze the prevalence of the most commonly observed...