Rajeev K Mehlotra
Overview
Explore the profile of Rajeev K Mehlotra including associated specialties, affiliations and a list of published articles.
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34
Citations
573
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Recent Articles
1.
Cramer E, Bartlett J, Chan E, Gaedigk A, Ratsimbasoa A, Mehlotra R, et al.
Pharmacogenomics
. 2023 Aug;
24(11):583-597.
PMID: 37551613
Antimalarial primaquine (PQ) eliminates liver hypnozoites of gene variation contributes to PQ therapeutic failure. Additional gene variation may contribute to PQ efficacy. Information on pharmacogenomic variation in Madagascar, with malaria...
2.
Ricky Chan E, Mehlotra R, Pirani K, Ratsimbasoa A, Williams S, Gaedigk A, et al.
Pharmacogenomics
. 2022 Mar;
23(5):315-325.
PMID: 35230160
malaria is endemic in Madagascar, where populations have genetic inheritance from Southeast Asia and East Africa. Primaquine, a drug of choice for vivax malaria, is metabolized principally via CYP2D6. variation...
3.
Mehlotra R, Gaedigk A, Howes R, Rakotomanga T, Ratsimbasoa A, Zimmerman P
Front Pharmacol
. 2021 May;
12:654054.
PMID: 33959023
is one of the five human malaria parasite species, which has a wide geographical distribution and can cause severe disease and fatal outcomes. It has the ability to relapse from...
4.
Mehlotra R
Infect Genet Evol
. 2020 Aug;
85:104512.
PMID: 32858232
Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed "cytokine storm"), is the major driver of pathology in severe...
5.
Mehlotra R
AIDS Res Hum Retroviruses
. 2020 Jul;
36(10):795-799.
PMID: 32615790
C-C chemokine receptor (CCR) 5 (CCR5) is the main HIV-1 coreceptor involved in virus entry and cell-to-cell spread during acute and chronic infections: such CCR5 and T cell tropic viruses...
6.
Mehlotra R
Cells
. 2019 Jul;
8(7).
PMID: 31261839
C-C chemokine receptor 5 () polymorphisms, particularly a 32-base pair deletion (∆32) in the open reading frame and -2459G > A in the promoter, are well known for their associations...
7.
Mehlotra R, Howes R, Cramer E, Tedrow R, Rakotomanga T, Ramboarina S, et al.
Am J Trop Med Hyg
. 2019 Mar;
100(5):1196-1201.
PMID: 30834883
Current malaria rapid diagnostic tests (RDTs) contain antibodies against -specific histidine-rich protein 2 (PfHRP2), lactate dehydrogenase (pLDH), and aldolase in various combinations. Low or high parasite densities/target antigen concentrations may...
8.
Mehlotra R
Curr HIV/AIDS Rep
. 2018 Sep;
15(6):431-440.
PMID: 30218255
Purpose Of Review: Human genetic polymorphisms known to influence HIV acquisition and disease progression occur in Papua New Guinea (PNG). However, no genetic association study has been reported so far....
9.
Willie B, Gare J, King C, Zimmerman P, Mehlotra R
P N G Med J
. 2018 Aug;
60(1-2):51-59.
PMID: 30147152
Polymorphisms in Toll-like receptor () and human β-defensin (hBD, encoded by ) genes have been evaluated for their associations with HIV infection and disease outcomes. Those studies, conducted in various...
10.
Willie N, Zimmerman P, Mehlotra R
Am J Trop Med Hyg
. 2018 Jul;
99(3):697-703.
PMID: 29968556
Histidine-rich protein 2 of (PfHRP2) forms the basis of many current malaria rapid diagnostic tests (RDTs). It is concerning that there are parasites that lack part or all of the...