A Preliminary Assessment of and Gene Polymorphisms in Papua New Guinea - What Does It Mean for HIV/AIDS?

Overview

Journal P N G Med J

Specialty General Medicine

Date 2018 Aug 28

PMID 30147152

Citations 1

Authors

Barne Willie

Janet Gare

Christopher L King

Peter A Zimmerman

Rajeev K Mehlotra

Affiliations

Soon will be listed here.

Abstract

Polymorphisms in Toll-like receptor () and human β-defensin (hBD, encoded by ) genes have been evaluated for their associations with HIV infection and disease outcomes. Those studies, conducted in various populations under a variety of study designs, generally revealed that specific single nucleotide polymorphisms (SNPs) in , 8, and genes, and copy number variation (CNV) in (encoding hBD-2), (encoding hBD-3), and (encoding hBD-4) genes are among potential genetic factors that can affect susceptibility to HIV infection and/or disease progression. The information regarding their prevalence in Papua New Guinea (PNG) is very limited for SNPs, and not available for CNV. The present study provides a preliminary assessment of these genetic polymorphisms in samples collected from the Wosera (East Sepik Province, n = 29) and Liksul (Madang Province, n = 23) areas. Wosera samples were analyzed for a total of 41 SNPs in 8 genes (, 8, and ), and both sample sets were analyzed for CNV in genes. A number of SNPs were not detected, and many other SNPs were present at low frequencies (minor allele frequencies ≤0.05) in the Wosera samples. The copy numbers were significantly different between the two sample sets (p = 0.024). Validation of these results, using larger sample sizes as well as samples from other areas of PNG, is warranted. In addition, genetic association studies are needed to estimate the effects of these polymorphisms on HIV infection and disease progression in PNG.

Citing Articles

Human Genetic Variation and HIV/AIDS in Papua New Guinea: Time to Connect the Dots.

Mehlotra R Curr HIV/AIDS Rep. 2018; 15(6):431-440.

PMID: 30218255 DOI: 10.1007/s11904-018-0417-9.

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