Pharmacogenomic Variation in the Malagasy Population: Implications for the Antimalarial Drug Primaquine Metabolism

Overview

Journal Pharmacogenomics

Specialties Genetics
Pharmacology

Date 2023 Aug 8

PMID 37551613

Authors

Estee Y Cramer

Jacquelaine Bartlett

Ernest R Chan

Andrea Gaedigk

Arsene C Ratsimbasoa

Rajeev K Mehlotra

Scott M Williams

Peter A Zimmerman

Affiliations

Soon will be listed here.

Abstract

Antimalarial primaquine (PQ) eliminates liver hypnozoites of gene variation contributes to PQ therapeutic failure. Additional gene variation may contribute to PQ efficacy. Information on pharmacogenomic variation in Madagascar, with malaria and a unique population admixture, is scanty. The authors performed genome-wide genotyping of 55 Malagasy samples and analyzed data with a focus on a set of 28 pharmacogenes most relevant to PQ. Mainly, the study identified 110 coding or splicing variants, including those that, based on previous studies in other populations, may be implicated in PQ response and copy number variation, specifically in chromosomal regions that contain pharmacogenes. With this pilot information, larger genome-wide association analyses with PQ metabolism and response are substantially more feasible.

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