Nir Hacohen
Overview
Explore the profile of Nir Hacohen including associated specialties, affiliations and a list of published articles.
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Articles
253
Citations
45470
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Recent Articles
1.
Millard N, Chen J, Palshikar M, Pelka K, Spurrell M, Price C, et al.
Genome Biol
. 2025 Feb;
26(1):36.
PMID: 40001084
Spatial transcriptomics facilitates gene expression analysis of cells in their spatial anatomical context. Batch effects hinder visualization of gene spatial patterns across samples. We present the Crescendo algorithm to correct...
2.
Braun D, Moranzoni G, Chea V, McGregor B, Blass E, Tu C, et al.
Nature
. 2025 Feb;
639(8054):474-482.
PMID: 39910301
Personalized cancer vaccines (PCVs) can generate circulating immune responses against predicted neoantigens. However, whether such responses can target cancer driver mutations, lead to immune recognition of a patient's tumour and...
3.
Gentili M, Carlson R, Liu B, Hellier Q, Andrews J, Qin Y, et al.
Cell Syst
. 2024 Dec;
15(12):1264-1277.e8.
PMID: 39657680
Stimulator of interferon genes (STING) traffics across intracellular compartments to trigger innate responses. Mutations in factors regulating this process lead to inflammatory disorders. To systematically identify factors involved in STING...
4.
Monette A, Aguilar-Mahecha A, Altinmakas E, Angelos M, Assad N, Batist G, et al.
Clin Cancer Res
. 2024 Dec;
31(3):439-456.
PMID: 39625818
With immuno-oncology becoming the standard of care for a variety of cancers, identifying biomarkers that reliably classify patient response, resistance, or toxicity becomes the next critical barrier toward improving care....
5.
Amit I, Ardlie K, Arzuaga F, Awandare G, Bader G, Bernier A, et al.
Nat Commun
. 2024 Nov;
15(1):10019.
PMID: 39567491
The Human Cell Atlas (HCA) is a global partnership "to create comprehensive reference maps of all human cells-the fundamental units of life - as a basis for both understanding human...
6.
Oh D, Kim E, Normand R, Lu G, Shook L, Lyall A, et al.
Cell Rep
. 2024 Nov;
43(11):114933.
PMID: 39504241
Pregnancy is a risk factor for increased severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory infections, but the mechanisms underlying this risk are poorly understood. To...
7.
Baillie J, Angus D, Burnham K, Calandra T, Calfee C, Gutteridge A, et al.
Intensive Care Med
. 2024 Oct;
50(12):2031-2042.
PMID: 39432104
Medical progress is reflected in the advance from broad clinical syndromes to mechanistically coherent diagnoses. By this metric, research in sepsis is far behind other areas of medicine-the word itself...
8.
Park R, Parikh M, Pappas L, Sade-Feldman M, Kulkarni A, Bi L, et al.
medRxiv
. 2024 Oct;
PMID: 39417106
Biliary tract cancers demonstrate profound therapeutic resistance, and broadly effective therapies for refractory disease are lacking. We conducted a single-arm, second-line phase II trial combining DKN-01, a humanized monoclonal antibody...
9.
LaFleur M, DAndrea J, Patterson D, Streeter I, Coxe M, Osborn J, et al.
J Immunol
. 2024 Oct;
213(10):1528-1541.
PMID: 39373572
CD8+ T cells differentiate into two subpopulations in response to acute viral infection: memory precursor effector cells (MPECs) and short-lived effector cells (SLECs). MPECs and SLECs are epigenetically distinct; however,...
10.
Chudnovskiy A, Castro T, Nakandakari-Higa S, Cui A, Lin C, Sade-Feldman M, et al.
Sci Immunol
. 2024 Oct;
9(100):eadq8843.
PMID: 39365874
Dendritic cells (DCs) are uniquely capable of transporting tumor antigens to tumor-draining lymph nodes (tdLNs) and interact with effector T cells in the tumor microenvironment (TME) itself, mediating both natural...