Raga Krishnakumar
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Explore the profile of Raga Krishnakumar including associated specialties, affiliations and a list of published articles.
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25
Citations
1714
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Recent Articles
1.
Goldberger Z, Hauert S, Chang K, Kurtanich T, Alpar A, Repond G, et al.
Cell Rep Med
. 2023 Aug;
4(8):101145.
PMID: 37552990
Immune checkpoint immunotherapy (ICI) can re-activate immune reactions against neoantigens, leading to remarkable remission in cancer patients. Nevertheless, only a minority of patients are responsive to ICI, and approaches for...
2.
High-Density Guide RNA Tiling and Machine Learning for Designing CRISPR Interference in sp. PCC 7002
Dallo T, Krishnakumar R, Kolker S, Ruffing A
ACS Synth Biol
. 2023 Mar;
12(4):1175-1186.
PMID: 36893454
While CRISPRi was previously established in sp. PCC 7002 (hereafter 7002), the design principles for guide RNA (gRNA) effectiveness remain largely unknown. Here, 76 strains of 7002 were constructed with...
3.
Robinson D, Foster M, Bennett C, Bhandarkar A, Webster E, Celebi A, et al.
Adv Mater
. 2022 Nov;
35(37):e2207595.
PMID: 36437049
Emerging concepts for neuromorphic computing, bioelectronics, and brain-computer interfacing inspire new research avenues aimed at understanding the relationship between oxidation state and conductivity in unexplored materials. This report expands the...
4.
Hirakawa M, Tjahjono N, Light Y, Celebi A, Celebi N, Chintalapudi P, et al.
iScience
. 2022 Feb;
25(2):103759.
PMID: 35141503
Mesenchymal stromal cells (MSCs) have broad-ranging therapeutic properties, including the ability to inhibit bacterial growth and resolve infection. However, the genetic mechanisms regulating these antibacterial properties in MSCs are largely...
5.
Krishnakumar R, Ruffing A
PLoS Comput Biol
. 2022 Jan;
18(1):e1009731.
PMID: 34986143
Operon prediction in prokaryotes is critical not only for understanding the regulation of endogenous gene expression, but also for exogenous targeting of genes using newly developed tools such as CRISPR-based...
6.
Hirakawa M, Krishnakumar R, Timlin J, Carney J, Butler K
Biosci Rep
. 2020 Mar;
40(4).
PMID: 32207531
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly interspaced short palindromic repeat DNA sequences)/Cas9 are rapidly progressing into clinical...
7.
Mageeney C, Lau B, Wagner J, Hudson C, Schoeniger J, Krishnakumar R, et al.
Nucleic Acids Res
. 2020 Mar;
48(8):4052-4065.
PMID: 32182341
Integrative genetic elements (IGEs) are mobile multigene DNA units that integrate into and excise from host bacterial genomes. Each IGE usually targets a specific site within a conserved host gene,...
8.
Edwards H, Krishnakumar R, Sinha A, Bird S, Patel K, Bartsch M
Sci Rep
. 2019 Nov;
9(1):17504.
PMID: 31745197
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Real-Time Selective Sequencing with RUBRIC: Read Until with Basecall and Reference-Informed Criteria
Edwards H, Krishnakumar R, Sinha A, Bird S, Patel K, Bartsch M
Sci Rep
. 2019 Aug;
9(1):11475.
PMID: 31391493
The Oxford MinION, the first commercial nanopore sequencer, is also the first to implement molecule-by-molecule real-time selective sequencing or "Read Until". As DNA transits a MinION nanopore, real-time pore current...
10.
Extraction and biomolecular analysis of dermal interstitial fluid collected with hollow microneedles
Miller P, Taylor R, Tran B, Boyd G, Glaros T, Chavez V, et al.
Commun Biol
. 2018 Oct;
1:173.
PMID: 30374463
Dermal interstitial fluid (ISF) is an underutilized information-rich biofluid potentially useful in health status monitoring applications whose contents remain challenging to characterize. Here, we present a facile microneedle approach for...