Ronald J Parchem
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Explore the profile of Ronald J Parchem including associated specialties, affiliations and a list of published articles.
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26
Citations
343
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Recent Articles
1.
Ye J, Boileau R, Parchem R, Judson-Torres R, Blelloch R
Stem Cells
. 2025 Mar;
43(2).
PMID: 40037390
The miR-290 and miR-302 clusters of microRNAs are highly expressed in naïve and primed pluripotent stem cells, respectively. Ectopic expression of the embryonic stem cell (ESC)-specific cell cycle regulating family...
2.
Ye J, Boileau R, Parchem R, Judson-Torres R, Blelloch R
bioRxiv
. 2024 Sep;
PMID: 39282363
Impact Statement: The process by which somatic cell reprogramming yields induced pluripotent stem cells (iPSCs) is incompletely understood. MicroRNAs from the miR-290 and miR-302 clusters have been shown to greatly...
3.
Reyes J, Tovy A, Zhang L, Bortoletto A, Rosas C, Chen C, et al.
iScience
. 2024 Jul;
27(7):110313.
PMID: 39027369
[This corrects the article DOI: 10.1016/j.isci.2024.109122.].
4.
Reyes J, Tovy A, Zhang L, Bortoletto A, Rosas C, Chen C, et al.
iScience
. 2024 Feb;
27(3):109122.
PMID: 38414863
During aging, blood cell production becomes dominated by a limited number of variant hematopoietic stem cell (HSC) clones. Differentiated progeny of variant HSCs are thought to mediate the detrimental effects...
5.
Cermakova K, Tao L, Dejmek M, Sala M, Montierth M, Chan Y, et al.
Nucleic Acids Res
. 2023 Nov;
52(1):4-21.
PMID: 37993417
Several cancer core regulatory circuitries (CRCs) depend on the sustained generation of DNA accessibility by SWI/SNF chromatin remodelers. However, the window when SWI/SNF is acutely essential in these settings has...
6.
Keuls R, Finnell R, Parchem R
Trends Endocrinol Metab
. 2023 Jul;
34(9):539-553.
PMID: 37468429
Changes in maternal nutrient availability due to diet or disease significantly increase the risk of neural tube defects (NTDs). Because the incidence of metabolic disease continues to rise, it is...
7.
Yang Z, Parchem R
Birth Defects Res
. 2023 Apr;
115(19):1785-1808.
PMID: 37066622
Congenital defects in the pancreas can cause severe health issues such as pancreatic cancer and diabetes which require lifelong treatment. Regenerating healthy pancreatic cells to replace malfunctioning cells has been...
8.
Bortoletto A, Parchem R
Neural Regen Res
. 2023 Apr;
18(10):2141-2146.
PMID: 37056121
Type 2 diabetes mellitus patients have a markedly higher risk of developing dementia. While multiple factors contribute to this predisposition, one of these involves the increased secretion of amylin, or...
9.
Bortoletto A, Parchem R
Cancer Res
. 2023 Mar;
83(10):1563-1572.
PMID: 36946612
Extensive studies have focused on the misregulation of individual miRNAs in cancer. More recently, mutations in the miRNA biogenesis and processing machinery have been implicated in several malignancies. Such mutations...
10.
Keuls R, Oh Y, Patel I, Parchem R
Proc Natl Acad Sci U S A
. 2023 Feb;
120(6):e2212578120.
PMID: 36724256
Developmental potential is progressively restricted after germ layer specification during gastrulation. However, cranial neural crest cells challenge this paradigm, as they develop from anterior ectoderm, yet give rise to both...