R Pamukcu
Overview
Explore the profile of R Pamukcu including associated specialties, affiliations and a list of published articles.
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25
Citations
797
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Recent Articles
1.
Liu L, Li H, Underwood T, Lloyd M, David M, Sperl G, et al.
J Pharmacol Exp Ther
. 2001 Oct;
299(2):583-92.
PMID: 11602670
These studies report on the activation and induction of cGMP-dependent protein kinase (PKG) by exisulind and analogs and test the hypothesis that PKG is involved in the induction of apoptosis...
2.
Piazza G, Thompson W, Pamukcu R, Alila H, WHITEHEAD C, Liu L, et al.
Cancer Res
. 2001 May;
61(10):3961-8.
PMID: 11358813
Exisulind (Aptosyn) is a novel antineoplastic drug being developed for the prevention and treatment of precancerous and malignant diseases. In colon tumor cells, the drug induces apoptosis by a mechanism...
3.
Myers C, Koki A, Pamukcu R, Wechter W, Padley R
Urology
. 2001 Apr;
57(4 Suppl 1):73-6.
PMID: 11295599
The very fact that apoptosis and nonsteroidal anti-inflammatory drugs (NSAIDs) can be linked in the same title should tell you that something unusual is happening. The image of NSAIDs among...
4.
Soh J, Mao Y, Liu L, Thompson W, Pamukcu R, Weinstein I
J Biol Chem
. 2001 Mar;
276(19):16406-10.
PMID: 11278263
We recently obtained evidence that treatment of human colon cancer cells with exisulind (sulindac sulfone) and related compounds induces apoptosis by activation of protein kinase G (PKG) and c-Jun kinase...
5.
Soh J, Mao Y, Kim M, Pamukcu R, Li H, Piazza G, et al.
Clin Cancer Res
. 2000 Oct;
6(10):4136-41.
PMID: 11051267
Sulindac sulfone (Exisulind) induces apoptosis and exhibits cancer chemopreventive activity, but in contrast to sulindac, it does not inhibit cyclooxygenases 1 or 2. We found that sulindac sulfone and two...
6.
Thompson W, Piazza G, Li H, Liu L, Fetter J, Zhu B, et al.
Cancer Res
. 2000 Jul;
60(13):3338-42.
PMID: 10910034
Sulindac sulfone (exisulind), although a nonsteroidal anti-inflammatory drug derivative, induces apoptosis in tumor cells by a mechanism that does not involve cyclooxygenase inhibition. SW480 colon tumor cells contain guanosine 3',5'-monophosphate...
7.
Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis
Stoner G, Budd G, Ganapathi R, DeYoung B, Kresty L, Nitert M, et al.
Adv Exp Med Biol
. 2000 Mar;
470:45-53.
PMID: 10709673
Sulindac sulfone (Exisulind), a metabolite of the non-steroidal anti-inflammatory drug, sulindac, was evalauted for its effects on the development of rectal polyps in patients with familial adenomatous polyposis. Three cohorts...
8.
Lim J, Piazza G, Han E, Delohery T, Li H, Finn T, et al.
Biochem Pharmacol
. 1999 Sep;
58(7):1097-107.
PMID: 10484067
We examined the activity of two metabolites of sulindac (a nonsteroidal anti-inflammatory drug), sulindac sulfide and sulindac sulfone (exisulind, Prevatec), and a novel highly potent analog of exisulind (CP248) on...
9.
Goluboff E, Shabsigh A, Saidi J, Weinstein I, Mitra N, Heitjan D, et al.
Urology
. 1999 Feb;
53(2):440-5.
PMID: 9933075
Objectives: Recent studies have shown that Exisulind, a sulfone metabolite of the nonsteroidal anti-inflammatory drug (NSAID) sulindac, has inhibitory activity in vitro with cultured human prostate cancer cells. To determine...
10.
Skopinska-Rozewska E, Piazza G, Sommer E, Pamukcu R, Barcz E, Filewska M, et al.
Int J Tissue React
. 1999 Jan;
20(3):85-9.
PMID: 9894180
The nonsteroidal antiinflammatory drug sulindac (sulfoxide) is known to cause regression and prevent recurrence of adenomas in patients with familial adenomatous polyposis. The mechanism of action does not appear to...