R D Schreiber
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Explore the profile of R D Schreiber including associated specialties, affiliations and a list of published articles.
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186
Citations
13460
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Recent Articles
21.
CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma
Mumberg D, Monach P, Wanderling S, Philip M, Toledano A, Schreiber R, et al.
Proc Natl Acad Sci U S A
. 1999 Jul;
96(15):8633-8.
PMID: 10411927
CD4(+) T cells can eliminate tumor cells in vivo in the absence of CD8(+) T cells. We have CD4(+) T cells specific for a MHC class II-restricted, tumor-specific peptide derived...
22.
Riley J, Takeda K, Akira S, Schreiber R
J Biol Chem
. 1999 May;
274(23):16513-21.
PMID: 10347215
Interleukin-10 (IL-10) is a cytokine that has pleiotropic effects on a variety of different cell types. Although many of the biologic responses induced by IL-10 are also induced by other...
23.
Jouanguy E, Lammas D, Dorman S, Fondaneche M, Dupuis S, Doffinger R, et al.
Nat Genet
. 1999 Apr;
21(4):370-8.
PMID: 10192386
The immunogenetic basis of severe infections caused by bacille Calmette-Guérin vaccine and environmental mycobacteria in humans remains largely unknown. We describe 18 patients from several generations of 12 unrelated families...
24.
Rodig S, KAPLAN D, Shankaran V, Old L, Schreiber R
Eur Cytokine Netw
. 1998 Nov;
9(3 Suppl):49-53.
PMID: 9831186
No abstract available.
25.
Migone T, Rodig S, Cacalano N, Berg M, Schreiber R, Leonard W
Mol Cell Biol
. 1998 Oct;
18(11):6416-22.
PMID: 9774657
Phosphatidylinositol 3-kinase (PI 3-K) plays an important role in signaling via a wide range of receptors such as those for antigen, growth factors, and a number of cytokines, including interleukin-2...
26.
Stark G, Kerr I, Williams B, Silverman R, Schreiber R
Annu Rev Biochem
. 1998 Oct;
67:227-64.
PMID: 9759489
Interferons play key roles in mediating antiviral and antigrowth responses and in modulating immune response. The main signaling pathways are rapid and direct. They involve tyrosine phosphorylation and activation of...
27.
Thomas H, Parker J, Schreiber R, Kay T
J Clin Invest
. 1998 Sep;
102(6):1249-57.
PMID: 9739059
We have generated transgenic nonobese diabetic (NOD) mice expressing dominant negative mutant IFN-gamma receptors on pancreatic beta cells to investigate whether the direct effects of IFN-gamma on beta cells contribute...
28.
Kaplan D, Shankaran V, Dighe A, STOCKERT E, Aguet M, Old L, et al.
Proc Natl Acad Sci U S A
. 1998 Jun;
95(13):7556-61.
PMID: 9636188
This study demonstrates that endogenously produced interferon gamma (IFN-gamma) forms the basis of a tumor surveillance system that controls development of both chemically induced and spontaneously arising tumors in mice....
29.
Rodig S, Meraz M, White J, Lampe P, Riley J, Arthur C, et al.
Cell
. 1998 May;
93(3):373-83.
PMID: 9590172
Herein we report the generation of mice lacking the ubiquitously expressed Janus kinase, Jak1. Jak1-/- mice are runted at birth, fail to nurse, and die perinatally. Although Jak1-/- cells are...
30.
Tanaka N, Sato M, Lamphier M, Nozawa H, Oda E, Noguchi S, et al.
Genes Cells
. 1998 May;
3(1):29-37.
PMID: 9581980
Background: The interferons (IFNs) have been extensively studied in the context of host defence against viral infection. In the established model of IFN action, virally infected cells secrete type I...