R A Prough
Overview
Explore the profile of R A Prough including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
129
Citations
761
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0
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Recent Articles
1.
Al-Eryani L, Wahlang B, Falkner K, Guardiola J, Clair H, Prough R, et al.
Toxicol Pathol
. 2014 Oct;
43(4):482-97.
PMID: 25326588
Background: Toxicant-associated fatty liver disease (TAFLD) is a recently identified form of nonalcoholic fatty liver disease (NAFLD) associated with exposure to industrial chemicals and environmental pollutants. Numerous studies have been...
2.
Green M, Pisano M, Prough R, Knudsen T
Cell Signal
. 2013 Aug;
25(12):2383-90.
PMID: 23899557
Increased accumulation of p53 tumor suppressor protein is an early response to low-level stressors. To investigate the fate of mitochondrial-sequestered p53, mouse embryonic fibroblast cells (MEFs) on a p53-deficient genetic...
3.
Makia N, Amunom I, Falkner K, Conklin D, Surapureddi S, Goldstein J, et al.
Mol Pharmacol
. 2012 Jun;
82(4):601-13.
PMID: 22740640
Previously we demonstrated that aldehyde dehydrogenase (ALDH) 1a1 is the major ALDH expressed in mouse liver and is an effective catalyst in metabolism of lipid aldehydes. Quantitative real-time polymerase chain...
4.
Green M, Singh A, Ruest L, Pisano M, Prough R, Knudsen T
Toxicology
. 2011 Sep;
290(1):31-41.
PMID: 21893155
Mitochondrial dysfunction has been implicated in chemical toxicities. The present study used an in vitro model to investigate the differential expression of metabolic pathways during cellular stress in p53-efficient embryonic...
5.
Robinzon B, Prough R
Arch Biochem Biophys
. 2009 May;
486(2):170-6.
PMID: 19416720
Human tissue from uninvolved liver of cancer patients was fractionated using differential centrifugation and characterized for 11betaHSD enzyme activity against corticosterone, dehydrocorticosterone, 7alpha- and 7beta-hydroxy-dehydroepiandrosterone, and 7-oxo-dehydroepiandrosterone. An enzyme activity...
6.
Falkner K, Ritter J, Prough R
Drug Metab Dispos
. 2007 Nov;
36(2):409-17.
PMID: 18039810
Glucocorticoids precociously induce fetal rat UGT1A6 and potentiate polycyclic aromatic hydrocarbon (PAH)-dependent induction of this enzyme in vivo and in isolated rat hepatocytes. To establish whether induction was due to...
7.
Pinaire J, Xiao G, Falkner K, Prough R
Toxicol Appl Pharmacol
. 2004 Sep;
199(3):344-53.
PMID: 15364549
Previous studies in neonatal and adolescent rats as well as adrenalectomized rats have demonstrated that glucocorticoids regulate the expression of the rat NAD(P)H:quinone oxidoreductase gene (QOR). We used primary cultures...
8.
Mandal P, McDaniel L, Prough R, Clark B
Toxicol Appl Pharmacol
. 2001 Sep;
175(3):200-8.
PMID: 11559018
Testosterone, which is essential for spermatogenesis, is synthesized in the Leydig cells of the testis. This study addresses whether male reproductive toxicity from exposure to polycyclic or polychlorinated aromatic hydrocarbons,...
9.
Falkner K, Pinaire J, Xiao G, Geoghegan T, Prough R
Mol Pharmacol
. 2001 Aug;
60(3):611-9.
PMID: 11502894
Glucocorticoids regulate the rat glutathione S-transferase A2 (GSTA2) gene in a biphasic manner in cultured hepatocytes that repress gene expression at low concentration (10--100 nM) but induce gene expression at...
10.
Klinge C, Jernigan S, Risinger K, Lee J, Tyulmenkov V, Falkner K, et al.
Arch Biochem Biophys
. 2001 May;
390(1):64-70.
PMID: 11368516
SHP (short heterodimer partner) is an orphan nuclear receptor lacking a DNA binding domain that interacts with nuclear receptors (NR) including thyroid receptor (TR), retinoic acid receptors (RAR and RXR),...