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Toxicologic Pathology

Toxicologic Pathology is a peer-reviewed journal that focuses on the study of toxicological effects on various organ systems and tissues. It publishes original research articles, reviews, and case reports, providing valuable insights into the mechanisms, diagnosis, and treatment of toxicological diseases. The journal serves as a platform for toxicologists, pathologists, and researchers to share their findings and advancements in the field of toxicologic pathology.
Details
Abbr. Toxicol Pathol
Publisher Sage Publications
Start 1978
End Continuing
Frequency Seven no. a year, 2005-
p-ISSN 0192-6233
e-ISSN 1533-1601
Country United States
Language English
Metrics
h-index / Ranks: 2115 124
SJR / Ranks: 7847 575
CiteScore / Ranks: 7049 3.80
JIF / Ranks: 6109 1.5
Recent Articles
1.
Recent Neuropathology Concepts
Maliver P, Boisclair J, Pardo I, Bell L, Hahn K, Pesti B, et al.
Toxicol Pathol . 2025 Mar; :1926233251320056. PMID: 40079493
The last session of the 2024 European Society of Toxicologic Pathology Congress was dedicated to recent neuro concepts, encompassing various topics including artificial intelligence (AI) applied to toxicologic pathology, new...
2.
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ()
Debien E, Goulet F, Silverman L, Millette E, Wu Q
Toxicol Pathol . 2025 Mar; :1926233251320080. PMID: 40079482
Two dark and raised foci were observed on the left hemisphere of the brain of a 3-year-old cynomolgus monkey during the routine necropsy procedures of a preclinical toxicity study. Microscopic...
3.
Comparisons of the Sensitivity of Histopathological and Immunohistochemical Analyses With Blood Hormone Levels for Early Detection of Antithyroid Effects in Rats Treated With Promoters of Thyroid Hormone Metabolism
Akane H, Toyoda T, Matsushita K, Uneyama M, Morikawa T, Kosaka T, et al.
Toxicol Pathol . 2025 Mar; :1926233251316880. PMID: 40079414
Although blood triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) levels are useful for detecting antithyroid compounds in rodent toxicity studies, there are challenges with high variability due to sampling...
4.
Molecular Pathology Methods to Characterize Biodistribution and Pharmacodynamics of the Oncolytic Virus VSV-GP in a Nonclinical Tumor Model
Matter A, Budzik K, Mehta S, Hoyt K, Dambra R, Vigil A, et al.
Toxicol Pathol . 2025 Feb; 53(1):65-82. PMID: 40013517
Replication-competent oncolytic virus (OV) therapies are a promising new modality for cancer treatment. However, they pose unique challenges for preclinical assessment, due in part to their tumor specificity and ability...
5.
Mitigating Nephrotoxicity Risks and Ranking Drug Candidates Using MALDI Mass Spectrometry Imaging: A Case Study
Chen B, LaFranco-Scheuch L, Dong S, Hernandez L, Mei H, Zhong W, et al.
Toxicol Pathol . 2025 Feb; 53(1):45-54. PMID: 40013516
Drug-induced nephrotoxicity is a major challenge in drug discovery and development, accounting for nearly a quarter of severe adverse effects in current pharmacotherapy. Antimicrobial use may be associated with this...
6.
2023 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: "Medical Device Safety Assessment: Pathology and Toxicology Perspective"
Wegener F, Alves A, Bussmeyer U, Soucy N
Toxicol Pathol . 2025 Feb; :1926233251316283. PMID: 39936568
Medical devices represent a complex category of medicinal products with varying definitions depending on the regional jurisdiction of regulatory agencies. A common aspect of these definitions is that a medical...
7.
Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development
Hahn K, Amberg B, Monne Rodriguez J, Verslegers M, Kang B, Wils H, et al.
Toxicol Pathol . 2025 Feb; 53(1):107-129. PMID: 39930627
Recent advances in bioanalytical and imaging technologies have revolutionized our ability to assess complex biological and pathological changes within tissue samples. Spatial omics, a rapidly evolving technology, enables the simultaneous...
8.
European Society of Toxicologic Pathology-Pathology 2.0 Mass Spectrometry Imaging Special Interest Group: Mass Spectrometry Imaging in Diagnostic and Toxicologic Pathology for Label-Free Detection of Molecules-From Basics to Practical Applications
Vezzali E, Becker M, Romero-Palomo F, van Heerden M, Chipeaux C, Hamm G, et al.
Toxicol Pathol . 2025 Feb; 53(1):130-158. PMID: 39902784
Mass Spectrometry Imaging (MSI) is a powerful tool to understand molecular pathophysiology and therapeutic and toxicity mechanisms, as well as for patient stratification and precision medicine. MSI, a label-free technique...
9.
Characterizing Antisense Oligonucleotide-Induced Histopathology Findings in Spinal Cord of Mauritius Cynomolgus Monkeys by Molecular Localization Investigation
Dubost V, Wuersch K, Penraat K, Johnson E, Wekkeli A, Ramakrishna R, et al.
Toxicol Pathol . 2025 Jan; 53(1):95-106. PMID: 39882764
The safety of a 2'--methoxyethyl antisense oligonucleotide (ASO) was investigated in Mauritius cynomolgus monkeys in a 41-week Good Laboratory Practice (GLP) toxicity study after multiple intrathecal (IT) administrations. Histopathological examination...
10.
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies
Guffroy M, Arndt T, Barale-Thomas E, Bolin S, Grevot A, Ibanes J, et al.
Toxicol Pathol . 2025 Jan; :1926233241309905. PMID: 39881485
Nonhuman primates (NHPs) have been and remain a highly valuable animal model with an essential role in translational research and pharmaceutical drug development. Based on current regulatory guidelines, the nonclinical...