R A Ashmun
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Explore the profile of R A Ashmun including associated specialties, affiliations and a list of published articles.
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56
Citations
3931
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Recent Articles
1.
Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, et al.
Cancer Res
. 2000 Feb;
60(3):722-7.
PMID: 10676659
Phage that display a surface peptide with the NGR sequence motif home selectively to tumor vasculature in vivo. A drug coupled to an NGR peptide has more potent antitumor effects...
2.
Gidding C, Germain G, Dilling M, Ashmun R, de Graaf S, Veverka K, et al.
Cancer Chemother Pharmacol
. 2000 Jan;
45(1):21-30.
PMID: 10647497
Purpose: Recombinant human insulin-like growth factor I (rhIGF-I) has been reported to ameliorate vincristine-induced neuropathy, the dose-limiting side effect of this antimitotic anticancer drug. However, rhIGF-I also might have adverse...
3.
McKenzie P, Guichard S, Middlemas D, Ashmun R, Danks M, Harris L
Clin Cancer Res
. 2000 Jan;
5(12):4199-207.
PMID: 10632361
p53 is a tumor suppressor protein important in the regulation of apoptosis. Because p53 functions as a transcription factor, cellular responses depend upon activity of p53 localized in the nucleus....
4.
Hegde S, Zhao J, Ashmun R, Shapiro L
Blood
. 1999 Sep;
94(5):1578-89.
PMID: 10477683
The transcriptional mechanisms that drive colony-forming unit granulocyte-macrophage (CFU-GM) myeloid progenitors to differentiate into cells of either the granulocytic or monocytic lineage are not fully understood. We have shown that...
5.
Hosoi H, Dilling M, Shikata T, Liu L, Shu L, Ashmun R, et al.
Cancer Res
. 1999 Feb;
59(4):886-94.
PMID: 10029080
The mammalian target of rapamycin (mTOR) has been shown to link growth factor signaling and posttranscriptional control of translation of proteins that are frequently involved in cell cycle progression. However,...
6.
Persons D, Allay J, Allay E, Ashmun R, Orlic D, Jane S, et al.
Blood
. 1999 Jan;
93(2):488-99.
PMID: 9885210
The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its role in normal adult hematopoiesis, a bicistronic retroviral...
7.
Allay J, Persons D, Galipeau J, Riberdy J, Ashmun R, Blakley R, et al.
Nat Med
. 1998 Oct;
4(10):1136-43.
PMID: 9771746
One of the main impediments to effective gene therapy of blood disorders is the resistance of human hematopoietic stem cells to stable genetic modification. We show here that a small...
8.
Altura R, Inukai T, Ashmun R, Zambetti G, Roussel M, Look A
Blood
. 1998 Aug;
92(4):1397-405.
PMID: 9694729
Leukemic lymphoblasts expressing the E2A-HLF oncoprotein possess wild-type p53 genes, but do not undergo apoptosis in response to DNA damage. Experimentally, E2A-HLF prevents apoptosis due to growth factor deprivation or...
9.
Davis J, Rock C, Cheng M, Watson J, Ashmun R, Kirk H, et al.
Mol Cell Biol
. 1997 Dec;
17(12):7398-406.
PMID: 9372970
Substitution of phenylalanine for tyrosine at codon 809 (Y809F) of the human colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) impairs ligand-stimulated tyrosine kinase activity, prevents induction of c-MYC and cyclin D1...
10.
Kamijo T, Zindy F, Roussel M, Quelle D, Downing J, Ashmun R, et al.
Cell
. 1997 Dec;
91(5):649-59.
PMID: 9393858
The INK4a tumor suppressor locus encodes p16INK4a, an inhibitor of cyclin D-dependent kinases, and p19ARF, an alternative reading frame protein that also blocks cell proliferation. Surprisingly, mice lacking p19ARF but...