C J Sherr
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Explore the profile of C J Sherr including associated specialties, affiliations and a list of published articles.
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215
Citations
19879
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Recent Articles
1.
Williams R, Sherr C
Cold Spring Harb Symp Quant Biol
. 2008 Nov;
73:461-7.
PMID: 19028987
Senescence and apoptosis programs governed by the Rb and p53 signaling networks can counter tissue stem cell self-renewal. A master regulator of Rb and p53 is the INK4-ARF (CDKN2A/B) locus...
2.
Sherr C, Bertwistle D, DEN Besten W, Kuo M, Sugimoto M, Tago K, et al.
Cold Spring Harb Symp Quant Biol
. 2006 Jul;
70:129-37.
PMID: 16869746
The Ink4a-Arf locus encodes two closely wedded tumor suppressor proteins (p16(Ink4a) and p19(Arf)) that inhibit cell proliferation by activating Rb and p53, respectively. With few exceptions, the Arf gene is...
3.
4.
Inoue K, Zindy F, Randle D, Rehg J, Sherr C
Genes Dev
. 2001 Nov;
15(22):2934-9.
PMID: 11711428
Loss of Dmp1, an Arf transcriptional activator, leads to spontaneous tumorigenesis in mice, causing death from various forms of cancer by two years of age. Retention and expression of the...
5.
Sherr C
Nat Rev Mol Cell Biol
. 2001 Oct;
2(10):731-7.
PMID: 11584300
The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either...
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7.
Randle D, Zindy F, Sherr C, Roussel M
Proc Natl Acad Sci U S A
. 2001 Aug;
98(17):9654-9.
PMID: 11481442
Establishment of cell lines from primary mouse embryo fibroblasts depends on loss of either the Arf tumor suppressor or its downstream target, the p53 transcription factor. Mouse p19(Arf) is encoded...
8.
Zindy F, DEN Besten W, Chen B, Rehg J, Latres E, Barbacid M, et al.
Mol Cell Biol
. 2001 Apr;
21(9):3244-55.
PMID: 11287627
Male mice lacking both the Ink4c and Ink4d genes, which encode two inhibitors of D-type cyclin-dependent kinases (Cdks), are infertile, whereas female fecundity is unaffected. Both p18(Ink4c) and p19(Ink4d) are...
9.
Weber J, Jeffers J, Rehg J, Randle D, Lozano G, Roussel M, et al.
Genes Dev
. 2000 Sep;
14(18):2358-65.
PMID: 10995391
The p19(ARF) tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop multiple tumors at a frequency...
10.