R A Ashmun
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Explore the profile of R A Ashmun including associated specialties, affiliations and a list of published articles.
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56
Citations
3931
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Recent Articles
11.
Persons D, Allay J, Allay E, Smeyne R, Ashmun R, Sorrentino B, et al.
Blood
. 1997 Sep;
90(5):1777-86.
PMID: 9292510
We have investigated the utility of the green fluorescent protein (GFP) to serve as a marker to assess retroviral gene transfer into hematopoietic cells and as a tool to identify...
12.
Quelle D, Cheng M, Ashmun R, Sherr C
Proc Natl Acad Sci U S A
. 1997 Jan;
94(2):669-73.
PMID: 9012842
The INK4a gene, one of the most frequently disrupted tumor suppressor loci in human cancer, encodes two unrelated proteins, p16INK4a and p19ARF, each of which is capable of inducing cell...
13.
Marathi U, HOWELL S, Ashmun R, Brent T
Blood
. 1996 Sep;
88(6):2298-305.
PMID: 8822951
Fanconi anemia (FA) cells are hypersensitive to cytotoxicity, cell cycle arrest, and chromosomal aberrations induced by DNA cross-linking agents, such as mitomycin C (MMC) and nitrogen mustard (HN2). Although MMC...
14.
Inaba T, Inukai T, Yoshihara T, Seyschab H, Ashmun R, Canman C, et al.
Nature
. 1996 Aug;
382(6591):541-4.
PMID: 8700228
The E2A-HLF (for hepatic leukaemia factor) fusion gene, formed by action of the t(17;19) (q22;p13) chromosomal translocation, drives the leukaemic transformation of early B-cell precursors, but the mechanism of this...
15.
Roussel M, Ashmun R, Sherr C, Eisenman R, Ayer D
Mol Cell Biol
. 1996 Jun;
16(6):2796-801.
PMID: 8649388
Mad1 is a basic helix-loop-helix-leucine zipper protein that is induced upon differentiation of a number of distinct cell types. Mad1 dimerizes with Max and recognizes the same DNA sequences as...
16.
Packham G, Ashmun R, Cleveland J
J Immunol
. 1996 Apr;
156(8):2792-800.
PMID: 8609398
Antioxidants suppress apoptosis induced by diverse stimuli in many cells, including immune cells, suggesting that reactive oxygen species (ROS) are common mediators of apoptosis. We evaluated the potential role for...
17.
Quelle D, Zindy F, Ashmun R, Sherr C
Cell
. 1995 Dec;
83(6):993-1000.
PMID: 8521522
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the retinoblastoma protein (pRB) and prevents exit from...
18.
Quelle D, Ashmun R, Hannon G, Rehberger P, Trono D, RICHTER K, et al.
Oncogene
. 1995 Aug;
11(4):635-45.
PMID: 7651726
Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-dependent kinases, cdk4 and cdk6. Genes encoding two specific inhibitors of these kinases, human...
19.
Hirai H, Roussel M, Kato J, Ashmun R, Sherr C
Mol Cell Biol
. 1995 May;
15(5):2672-81.
PMID: 7739547
Cyclin D-dependent kinases act as mitogen-responsive, rate-limiting controllers of G1 phase progression in mammalian cells. Two novel members of the mouse INK4 gene family, p19 and p18, that specifically inhibit...
20.
Inaba T, Shapiro L, Funabiki T, Sinclair A, Jones B, Ashmun R, et al.
Mol Cell Biol
. 1994 May;
14(5):3403-13.
PMID: 8164688
Hybrid transcription factors, resulting from gene fusions in the wake of chromosomal translocations, have been implicated in leukemogenesis, but their precise contributions to oncogenic conversion remain unclear. The E2A-HLF fusion...