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Priyanka Sehgal

Explore the profile of Priyanka Sehgal including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 76
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Recent Articles
1.
Sehgal P, Naqvi A, Higgins M, Liu J, Harvey K, Jarroux J, et al.
bioRxiv . 2025 Jan; PMID: 39868324
Statement Of Significance: Existing targets for chimeric antigen receptors (CAR)-armed T cells are often shared by CNS tumors and normal tissues, creating the potential for on-target/off-tumor toxicities. Here we demonstrate...
2.
Anczukow O, Allain F, Angarola B, Black D, Brooks A, Cheng C, et al.
Nat Rev Cancer . 2024 Oct; 24(12):887-905. PMID: 39384951
Splicing factors are affected by recurrent somatic mutations and copy number variations in several types of haematologic and solid malignancies, which is often seen as prima facie evidence that splicing...
3.
Torres-Diz M, Reglero C, Falkenstein C, Castro A, Hayer K, Radens C, et al.
Cancer Res . 2024 Aug; 84(20):3327-3336. PMID: 39094066
Relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) is a major cause of pediatric cancer-related deaths. Relapse-specific mutations do not account for all chemotherapy failures in B-ALL patients, suggesting additional...
4.
Torres-Diz M, Reglero C, Falkenstein C, Castro A, Hayer K, Radens C, et al.
bioRxiv . 2024 Aug; PMID: 39091882
Relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) is a major cause of pediatric cancer-related deaths. Relapse-specific mutations do not account for all chemotherapy failures in B- ALL patients, suggesting...
5.
Li N, Zhu Q, Tian Y, Ahn K, Wang X, Cramer Z, et al.
Nat Commun . 2023 Nov; 14(1):7915. PMID: 38036590
The initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding the function of specific cancer-TME interactions poses a major challenge due in part to the...
6.
Sehgal P, Lanauze C, Wang X, Hayer K, Torres-Diz M, Leu N, et al.
Mol Cancer Res . 2021 Oct; 19(12):2003-2014. PMID: 34593610
Activation of Wnt signaling is among the earliest events in colon cancer development. It is achieved either via activating mutations in the gene encoding β-catenin, the key transcription factor in...
7.
Lanauze C, Sehgal P, Hayer K, Torres-Diz M, Pippin J, Grant S, et al.
Mol Cancer Res . 2021 Feb; 19(5):823-833. PMID: 33608451
About 10% to 30% of patients with colorectal cancer harbor either loss of or missense mutations in SMAD4, a critical component of the TGFβ signaling pathway. The pathophysiologic function of...
8.
Li C, Hancock M, Sehgal P, Zhou S, Reinhardt D, Philip A
Biochem J . 2015 Dec; 473(5):537-47. PMID: 26621871
Transforming growth factor-β (TGF-β) is a multifunctional cytokine implicated in many diseases, including tissue fibrosis and cancer. TGF-β mediates diverse biological responses by signalling through type I and II TGF-β...
9.
Praveen Kumar V, Sehgal P, Thota B, Patil S, Santosh V, Kondaiah P
J Neurooncol . 2014 Jan; 116(3):455-64. PMID: 24395346
Insulin like growth factor binding protein 4 (IGFBP4) regulates growth and development of tissues and organs by negatively regulating IGF signaling. Among most cancers, IGFBP4 has growth inhibitory role and...
10.
Sehgal P, Kumar N, Praveen Kumar V, Patil S, Bhattacharya A, Vijaya Kumar M, et al.
Mol Cancer . 2013 Jun; 12:63. PMID: 23767917
Background: Insulin like growth factor binding proteins modulate the mitogenic and pro survival effects of IGF. Elevated expression of IGFBP2 is associated with progression of tumors that include prostate, ovarian,...