Andrei Thomas-Tikhonenko
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Explore the profile of Andrei Thomas-Tikhonenko including associated specialties, affiliations and a list of published articles.
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84
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4830
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Recent Articles
1.
Sehgal P, Naqvi A, Higgins M, Liu J, Harvey K, Jarroux J, et al.
bioRxiv
. 2025 Jan;
PMID: 39868324
Statement Of Significance: Existing targets for chimeric antigen receptors (CAR)-armed T cells are often shared by CNS tumors and normal tissues, creating the potential for on-target/off-tumor toxicities. Here we demonstrate...
2.
Anczukow O, Allain F, Angarola B, Black D, Brooks A, Cheng C, et al.
Nat Rev Cancer
. 2024 Oct;
24(12):887-905.
PMID: 39384951
Splicing factors are affected by recurrent somatic mutations and copy number variations in several types of haematologic and solid malignancies, which is often seen as prima facie evidence that splicing...
3.
Han S, Jewell S, Thomas-Tikhonenko A, Barash Y
Genome Res
. 2024 Sep;
34(10):1624-1635.
PMID: 39322279
Mapping transcriptomic variations using either short- or long-read RNA sequencing is a staple of genomic research. Long reads are able to capture entire isoforms and overcome repetitive regions, whereas short...
4.
Naqvi A, Corbett R, Seghal P, Conkrite K, Rathi K, Ennis B, et al.
bioRxiv
. 2024 Aug;
PMID: 39149264
Pediatric brain cancer is the leading cause of disease-related mortality in children, and many aggressive tumors still lack effective treatment strategies. We characterized aberrant alternative splicing across pediatric brain tumors,...
5.
Torres-Diz M, Reglero C, Falkenstein C, Castro A, Hayer K, Radens C, et al.
Cancer Res
. 2024 Aug;
84(20):3327-3336.
PMID: 39094066
Relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) is a major cause of pediatric cancer-related deaths. Relapse-specific mutations do not account for all chemotherapy failures in B-ALL patients, suggesting additional...
6.
Torres-Diz M, Reglero C, Falkenstein C, Castro A, Hayer K, Radens C, et al.
bioRxiv
. 2024 Aug;
PMID: 39091882
Relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) is a major cause of pediatric cancer-related deaths. Relapse-specific mutations do not account for all chemotherapy failures in B- ALL patients, suggesting...
7.
8.
Han S, Jewell S, Thomas-Tikhonenko A, Barash Y
bioRxiv
. 2023 Dec;
PMID: 38045232
Mapping transcriptomic variations using either short or long reads RNA sequencing is a staple of genomic research. Long reads are able to capture entire isoforms and overcome repetitive regions, while...
9.
Li N, Zhu Q, Tian Y, Ahn K, Wang X, Cramer Z, et al.
Nat Commun
. 2023 Nov;
14(1):7915.
PMID: 38036590
The initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding the function of specific cancer-TME interactions poses a major challenge due in part to the...
10.
Quesnel-Vallieres M, Jewell S, Lynch K, Thomas-Tikhonenko A, Barash Y
Nucleic Acids Res
. 2023 Nov;
52(D1):D213-D221.
PMID: 37953365
Quantification of RNA splicing variations based on RNA-Sequencing can reveal tissue- and disease-specific splicing patterns. To study such splicing variations, we introduce MAJIQlopedia, an encyclopedia of splicing variations that encompasses...