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Prem P Chapagain

Explore the profile of Prem P Chapagain including associated specialties, affiliations and a list of published articles. Areas
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Articles 72
Citations 524
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Recent Articles
1.
Su L, Deng Z, Santos-Fernandez M, Jeanne Dit Fouque K, Chapagain P, Chambers J, et al.
Nucleic Acids Res . 2025 Jan; 53(3). PMID: 39873271
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a small DNA-binding protein that specifically targets AT-rich DNA sequences. Structurally, HMGA2 is an intrinsically disordered protein (IDP), comprising three...
2.
Gautam N, Chapagain P, Adhikari N, Tiwari P
J Biomol Struct Dyn . 2024 Dec; :1-10. PMID: 39660765
Interactions of transcriptional corepressors such as histone deacetylase 7 (HDAC7), a class IIa HDAC, with myocyte enhancer factor-2 (MEF2) regulate MEF2 activity. Despite previous investigations exploring interactions between HDAC7 and...
3.
Hossen M, Bhattarai N, Chapagain P, Gerstman B
Methods Mol Biol . 2024 Nov; 2870:315-340. PMID: 39543042
Multi-antimicrobial extrusion (MATE) transporter membrane proteins provide drug and toxin resistivity by expelling compounds from cells. MATE proteins can be pictured as V-shaped. To regulate its functioning, the protein structure...
4.
Perez H, Wang Z, Gerstman B, He J, Chapagain P
J Chem Inf Model . 2024 Oct; 64(20):7977-7986. PMID: 39370850
The lantibiotic pore-forming peptide nisin is a promising candidate in the fight against multidrug-resistant bacteria due to its unique structure, which allows it to disrupt bacteria in two distinct ways─Lipid...
5.
Cioffi M, Sharma T, Motsa B, Bhattarai N, Gerstman B, Stahelin R, et al.
J Phys Chem B . 2024 Sep; 128(46):11335-11344. PMID: 39326870
Viral proteins frequently undergo single or multiple amino acid mutations during replication, which can significantly alter their functionality. The Ebola virus matrix protein VP40 is multifunctional but primarily responsible for...
6.
Narkhede Y, Saxena R, Sharma T, Conarty J, Ramirez V, Motsa B, et al.
Protein Sci . 2024 Apr; 33(5):e4978. PMID: 38591637
The Ebola virus (EBOV) is a lipid-enveloped virus with a negative sense RNA genome that can cause severe and often fatal viral hemorrhagic fever. The assembly and budding of EBOV...
7.
Motsa B, Sharma T, Cioffi M, Chapagain P, Stahelin R
J Biol Chem . 2024 Mar; 300(5):107213. PMID: 38522519
Ebola virus (EBOV) is a filamentous negative-sense RNA virus, which causes severe hemorrhagic fever. There are limited vaccines or therapeutics for prevention and treatment of EBOV, so it is important...
8.
Cioffi M, Husby M, Gerstman B, Stahelin R, Chapagain P
Biochim Biophys Acta Mol Cell Biol Lipids . 2024 Feb; 1869(3):159464. PMID: 38360201
The Ebola virus matrix protein VP40 is responsible for the formation of the viral matrix by localizing at the inner leaflet of the human plasma membrane (PM). Various lipid types,...
9.
Motsa B, Sharma T, Chapagain P, Stahelin R
bioRxiv . 2024 Feb; PMID: 38352396
Ebola virus (EBOV) is a filamentous negative-sense RNA virus which causes severe hemorrhagic fever. There are limited vaccines or therapeutics for prevention and treatment of EBOV, so it is important...
10.
Johnson K, Budicini M, Bhattarai N, Sharma T, Urata S, Gerstman B, et al.
J Lipid Res . 2024 Jan; 65(3):100512. PMID: 38295986
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a...