Piotr A Mieczkowski
Overview
Explore the profile of Piotr A Mieczkowski including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
74
Citations
5554
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Porcher L, Vijayraghavan S, Patel Y, Becker S, Blouin T, McCollum J, et al.
Genetics
. 2024 Dec;
PMID: 39707916
Acetaldehyde is the primary metabolite of alcohol and is present in many environmental sources including tobacco smoke. Acetaldehyde is genotoxic, whereby it can form DNA adducts and lead to mutagenesis....
2.
Franklin J, Testen A, Mieczkowski P, Hepperla A, Crynen G, Simon J, et al.
bioRxiv
. 2024 Aug;
PMID: 39149305
In recent years, astrocytes have been increasingly implicated in cellular mechanisms of substance use disorders (SUD). Astrocytes are structurally altered following exposure to drugs of abuse; specifically, astrocytes within the...
3.
Kadyrova L, Mieczkowski P, Kadyrov F
J Biol Chem
. 2024 May;
300(6):107406.
PMID: 38782208
The DNA mismatch repair (MMR) system promotes genome stability and protects humans from certain types of cancer. Its primary function is the correction of DNA polymerase errors. MutLα is an...
4.
Kadyrova L, Mieczkowski P, Kadyrov F
bioRxiv
. 2024 Apr;
PMID: 38617288
The DNA mismatch repair (MMR) system promotes genome stability and protects humans from certain types of cancer. Its primary function is the correction of DNA polymerase errors. MutLα is an...
5.
Porcher L, Vijayraghavan S, McCollum J, Mieczkowski P, Saini N
bioRxiv
. 2024 Jan;
PMID: 38260495
Acetaldehyde is the primary metabolite of alcohol and is present in many environmental sources including tobacco smoke. Acetaldehyde is genotoxic, whereby it can form DNA adducts and lead to mutagenesis....
6.
Hudson K, Klimczak L, Sterling J, Burkholder A, Kazanov M, Saini N, et al.
Nucleic Acids Res
. 2023 Jul;
51(17):9075-9100.
PMID: 37471042
Mutagens often prefer specific nucleotides or oligonucleotide motifs that can be revealed by studying the hypermutation spectra in single-stranded (ss) DNA. We utilized a yeast model to explore mutagenesis by...
7.
Laughery M, Plummer D, Wilson H, Vandenberg B, Mitchell D, Mieczkowski P, et al.
Genetics
. 2023 May;
224(3).
PMID: 37170598
Ultraviolet (UV) light primarily causes C > T substitutions in lesion-forming dipyrimidine sequences. However, many of the key driver mutations in melanoma do not fit this canonical UV signature, but...
8.
Vandenberg B, Laughery M, Cordero C, Plummer D, Mitchell D, Kreyenhagen J, et al.
Nat Commun
. 2023 May;
14(1):2576.
PMID: 37142570
UV exposure induces a mutation signature of C > T substitutions at dipyrimidines in skin cancers. We recently identified additional UV-induced AC > TT and A > T substitutions that...
9.
Kadyrova L, Mieczkowski P, Kadyrov F
J Biol Chem
. 2023 Apr;
299(5):104705.
PMID: 37059180
The DNA mismatch repair (MMR) system is a major DNA repair system that suppresses both inherited and sporadic cancers in humans. In eukaryotes, the MutSα-dependent and MutSβ-dependent MMR pathways correct...
10.
Vijayraghavan S, Porcher L, Mieczkowski P, Saini N
Nucleic Acids Res
. 2022 Jul;
50(13):7451-7464.
PMID: 35776120
Acetaldehyde (AA), a by-product of ethanol metabolism, is acutely toxic due to its ability to react with various biological molecules including DNA and proteins, which can greatly impede key processes...