Steven A Roberts
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Explore the profile of Steven A Roberts including associated specialties, affiliations and a list of published articles.
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74
Citations
6270
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Recent Articles
1.
Brown R, Coxon M, Larsen B, Allison M, Chadha A, Mittelstadt I, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2408179122.
PMID: 39772743
CAG/CTG repeats are prone to expansion, causing several inherited human diseases. The initiating sources of DNA damage which lead to inaccurate repair of the repeat tract to cause expansions are...
2.
Cordero C, Mehta K, Weaver T, Ling J, Freudenthal B, Cortez D, et al.
Nat Commun
. 2024 Dec;
15(1):10722.
PMID: 39715760
8-oxoguanine (8-oxoG) is a common oxidative DNA lesion that causes G > T substitutions. Determinants of local and regional differences in 8-oxoG-induced mutability across genomes are currently unknown. Here, we...
3.
Dennen M, Kockler Z, Roberts S, Burkholder A, Klimczak L, Gordenin D
G3 (Bethesda)
. 2024 Aug;
14(10).
PMID: 39150943
Human APOBEC single-strand (ss) specific DNA and RNA cytidine deaminases change cytosines to uracils (U's) and function in antiviral innate immunity and RNA editing and can cause hypermutation in chromosomes....
4.
Patil S, Roberts S, Gebremedhin A
Front Bioinform
. 2024 Jul;
4:1365200.
PMID: 39040139
Cancer is a heterogeneous disease that results from genetic alteration of cell cycle and proliferation controls. Identifying mutations that drive cancer, understanding cancer type specificities, and delineating how driver mutations...
5.
Dennen M, Kockler Z, Roberts S, Burkholder A, Klimczak L, Gordenin D
bioRxiv
. 2024 Jul;
PMID: 38979205
Human APOBEC single-strand (ss) specific DNA and RNA cytidine deaminases change cytosines to uracils and function in antiviral innate immunity, RNA editing, and can cause hypermutation in chromosomes. The resulting...
6.
Dennis M, Hurley A, Bray N, Cordero C, Ilagan J, Mertz T, et al.
PLoS Genet
. 2024 May;
20(5):e1011293.
PMID: 38805570
APOBEC-induced mutations occur in 50% of sequenced human tumors, with APOBEC3A (A3A) being a major contributor to mutagenesis in breast cancer cells. The mechanisms that cause A3A activation and mutagenesis...
7.
Coxon M, Dennis M, Dananberg A, Collins C, Wilson H, Meekma J, et al.
NAR Cancer
. 2023 Dec;
5(4):zcad058.
PMID: 38155930
Apolipoprotein B messenger RNA (mRNA) editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminases cause genetic instability during cancer development. Elevated APOBEC3A (A3A) levels result in APOBEC signature mutations; however, mechanisms regulating...
8.
Mertz T, Rice-Reynolds E, Nguyen L, Wood A, Cordero C, Bray N, et al.
Genome Res
. 2023 Aug;
33(9):1568-1581.
PMID: 37532520
The cytidine deaminases APOBEC3A (A3A) and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we used a screen...
9.
Laughery M, Plummer D, Wilson H, Vandenberg B, Mitchell D, Mieczkowski P, et al.
Genetics
. 2023 May;
224(3).
PMID: 37170598
Ultraviolet (UV) light primarily causes C > T substitutions in lesion-forming dipyrimidine sequences. However, many of the key driver mutations in melanoma do not fit this canonical UV signature, but...
10.
Vandenberg B, Laughery M, Cordero C, Plummer D, Mitchell D, Kreyenhagen J, et al.
Nat Commun
. 2023 May;
14(1):2576.
PMID: 37142570
UV exposure induces a mutation signature of C > T substitutions at dipyrimidines in skin cancers. We recently identified additional UV-induced AC > TT and A > T substitutions that...