Adam B Burkholder
Overview
Explore the profile of Adam B Burkholder including associated specialties, affiliations and a list of published articles.
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38
Citations
854
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Recent Articles
1.
Williams J, Lujan S, Arana M, Burkholder A, Tumbale P, Williams R, et al.
Nat Commun
. 2024 Oct;
15(1):8730.
PMID: 39379399
Finalization of eukaryotic nuclear DNA replication relies on DNA ligase 1 (LIG1) to seal DNA nicks generated during Okazaki Fragment Maturation (OFM). Using a mutational reporter in Saccharomyces cerevisiae, we...
2.
Marks S, Zhou Z, Lujan S, Burkholder A, Kunkel T
DNA Repair (Amst)
. 2024 Sep;
143:103768.
PMID: 39332392
We show that the rates of single base substitutions, additions, and deletions across the nuclear genome are strongly increased in a strain harboring a mutator variant of DNA polymerase α...
3.
Dennen M, Kockler Z, Roberts S, Burkholder A, Klimczak L, Gordenin D
G3 (Bethesda)
. 2024 Aug;
14(10).
PMID: 39150943
Human APOBEC single-strand (ss) specific DNA and RNA cytidine deaminases change cytosines to uracils (U's) and function in antiviral innate immunity and RNA editing and can cause hypermutation in chromosomes....
4.
Lujan S, Garbacz M, Liberti S, Burkholder A, Kunkel T
Nucleic Acids Res
. 2024 Jul;
52(16):9574-9585.
PMID: 39016170
The endonuclease activity of Pms1 directs mismatch repair by generating a nick in the newly replicated DNA strand. Inactivating Pms2, the human homologue of yeast Pms1, increases the chances of...
5.
Dennen M, Kockler Z, Roberts S, Burkholder A, Klimczak L, Gordenin D
bioRxiv
. 2024 Jul;
PMID: 38979205
Human APOBEC single-strand (ss) specific DNA and RNA cytidine deaminases change cytosines to uracils and function in antiviral innate immunity, RNA editing, and can cause hypermutation in chromosomes. The resulting...
6.
Hoang T, Lee Y, McCartney D, Kersten E, Page C, Hulls P, et al.
EBioMedicine
. 2024 Jan;
100:104956.
PMID: 38199042
Background: Smoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (<1 year), persistence of differential methylation from in utero...
7.
Snyder B, Huang R, Burkholder A, Donahue D, Mahler B, Bortner C, et al.
Life Sci Alliance
. 2023 Oct;
7(1).
PMID: 37903626
Members of the tristetraprolin (TTP) family of RNA-binding proteins can bind to and promote the decay of specific transcripts containing AU-rich motifs. ZFP36 (TTP) is best known for regulating pro-inflammatory...
8.
Dobson N, Kleeberger S, Burkholder A, Walters D, Gladwell W, Gerrish K, et al.
Int J Mol Sci
. 2023 Oct;
24(19).
PMID: 37833956
Interstitial lung diseases (ILDs) are lethal lung diseases characterized by pulmonary inflammation and progressive lung interstitial scarring. We previously developed a mouse model of ILD using vanadium pentoxide (VO) and...
9.
Hudson K, Klimczak L, Sterling J, Burkholder A, Kazanov M, Saini N, et al.
Nucleic Acids Res
. 2023 Jul;
51(17):9075-9100.
PMID: 37471042
Mutagens often prefer specific nucleotides or oligonucleotide motifs that can be revealed by studying the hypermutation spectra in single-stranded (ss) DNA. We utilized a yeast model to explore mutagenesis by...
10.
Lee E, Choi W, Burkholder A, Perera L, Mack J, Miller F, et al.
Front Genet
. 2023 Jul;
14:1173676.
PMID: 37415598
Asthma is a chronic disease of the airways that impairs normal breathing. The etiology of asthma is complex and involves multiple factors, including the environment and genetics, especially the distinct...