Pierre H Vachon
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Explore the profile of Pierre H Vachon including associated specialties, affiliations and a list of published articles.
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25
Citations
634
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Recent Articles
1.
Gagne D, Benoit Y, Groulx J, Vachon P, Beaulieu J
BMC Mol Cell Biol
. 2020 Mar;
21(1):14.
PMID: 32183701
Background: Fibronectin (FN) assembly into an insoluble fibrillar matrix is a crucial step in many cell responses to extracellular matrix (ECM) properties, especially with regards to the integrin-related mechanosensitive signaling...
2.
Vachon P
Methods Mol Biol
. 2018 Mar;
1765:99-137.
PMID: 29589304
Caspase-dependent apoptosis, including its distinct cell death subroutine known as anoikis, perform essential roles during organogenesis, as well as in the maintenance and repair of tissues. To this effect, the...
3.
Boudjadi S, Bernatchez G, Senicourt B, Beausejour M, Vachon P, Carrier J, et al.
Cancers (Basel)
. 2017 Sep;
9(8).
PMID: 28933766
Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling that participate in the regulation of cell shape, adhesion, migration, survival and proliferation. The integrin α1β1 is known...
4.
Mikhail M, Vachon P, DOrleans-Juste P, Jacques D, Bkaily G
Can J Physiol Pharmacol
. 2017 Jul;
95(10):1298-1305.
PMID: 28732172
Our previous work showed the presence of endothelin-1 (ET-1) receptors, ET and ET, in human vascular endothelial cells (hVECs). In this study, we wanted to verify whether ET-1 plays a...
5.
Roostaee A, Guezguez A, Beausejour M, Simoneau A, Vachon P, Levy E, et al.
J Cell Biochem
. 2015 Jul;
116(11):2695-708.
PMID: 26129821
Mechanisms that maintain proliferation and delay cell differentiation in the intestinal crypt are not yet fully understood. We have previously shown the implication of histone methylation in the regulation of...
6.
Pomerleau V, Landry M, Bernier J, Vachon P, Saucier C
BMC Cancer
. 2014 Apr;
14:240.
PMID: 24708867
Background: Deregulation of receptor tyrosine kinases (RTK) contributes to the initiation and progression of intestinal-derived epithelial cancers, including colorectal cancer (CRC). However, the roles of the proximal signaling molecules engaged...
7.
Beausejour M, Thibodeau S, Demers M, Bouchard V, Gauthier R, Beaulieu J, et al.
BMC Cell Biol
. 2013 Dec;
14:53.
PMID: 24289209
Background: Regulation of anoikis in human intestinal epithelial cells (IECs) implicates differentiation state-specific mechanisms. Human IECs express distinct repertoires of integrins according to their state of differentiation. Therefore, we investigated...
8.
Beausejour M, Noel D, Thibodeau S, Bouchard V, Harnois C, Beaulieu J, et al.
Apoptosis
. 2012 Mar;
17(6):566-78.
PMID: 22402981
In human intestinal epithelial crypt (HIEC) cells, the PI3-K/Akt-1 pathway is crucial for the promotion of cell survival and suppression of anoikis. Class I PI3-K consists of a complex formed...
9.
Vachon P
J Signal Transduct
. 2011 Jul;
2011:738137.
PMID: 21785723
Cell survival and apoptosis implicate an increasing complexity of players and signaling pathways which regulate not only the decision-making process of surviving (or dying), but as well the execution of...
10.
Benoit Y, Larrivee J, Groulx J, Stankova J, Vachon P, Beaulieu J
Biochem Biophys Res Commun
. 2010 Aug;
399(3):434-9.
PMID: 20678483
We previously reported that integrin alpha8beta1 is expressed in human intestinal epithelial crypt cells (HIECs) and represents one of the major RGD-binding integrins expressed by these cells. Moreover, the depletion...