Dieter Willbold
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Explore the profile of Dieter Willbold including associated specialties, affiliations and a list of published articles.
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311
Citations
10269
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Recent Articles
1.
Korkmaz H, Anstotz M, Wellinghof T, Fazari B, Hallenberger A, Bergmann A, et al.
Front Cell Neurosci
. 2025 Mar;
19:1538985.
PMID: 40083633
Introduction: Glutamate represents the dominant neurotransmitter that conveys the light information to the brain, including the suprachiasmatic nucleus (SCN), the central pacemaker for the circadian system. The neuronal and astrocytic...
2.
Leveille A, Schwarzrock T, Brown H, True B, Plasencia J, Neudecker P, et al.
ACS Med Chem Lett
. 2025 Feb;
16(2):271-277.
PMID: 39967642
We report the first structure-activity studies of arylidene-indolinone compound , which was reported as a ligand of autophagy-related protein LC3B. The literature has conflicting information on the binding affinity of...
3.
Blomeke L, Rehn F, Pils M, Kraemer-Schulien V, Cousin A, Kutzsche J, et al.
Commun Med (Lond)
. 2024 Dec;
4(1):262.
PMID: 39658587
Background: Quantification of Amyloid beta (Aβ) oligomers in plasma enables early diagnosis of Alzheimer's Disease (AD) and improves our understanding of underlying pathologies. However, quantification necessitates an extremely sensitive and...
4.
Rettie S, Juergens D, Adebomi V, Bueso Y, Zhao Q, Leveille A, et al.
bioRxiv
. 2024 Nov;
PMID: 39605685
The development of macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource-intensive and provide little control over binding mode. Despite considerable progress in physics-based methods...
5.
Leveille A, Schwarzrock T, Brown H, True B, Plasencia J, Neudecker P, et al.
bioRxiv
. 2024 Nov;
PMID: 39554136
We report the first structure-activity studies of arylidene-indolinone compound which was reported as a ligand of autophagy-related protein LC3B. The literature has conflicting information on the binding affinity of this...
6.
Pils M, Dybala A, Schaffrath A, Rehn F, Kutzsche J, Blomeke L, et al.
Alzheimers Res Ther
. 2024 Oct;
16(1):223.
PMID: 39402637
Background: Misfolding and aggregation of amyloid β (Aβ), along with neurofibrillary tangles consisting of aggregated Tau species, are pathological hallmarks of Alzheimer's disease (AD) onset and progression. In this study,...
7.
Rehn F, Kraemer-Schulien V, Bujnicki T, Bannach O, Tschoepe D, Stratmann B, et al.
Sci Rep
. 2024 Aug;
14(1):19556.
PMID: 39174611
Islet amyloid polypeptide (IAPP) is co-secreted with insulin from pancreatic ß-cells. Its oligomerisation is regarded as disease driving force in type 2 diabetes (T2D) pathology. Up to now, IAPP oligomers...
8.
Uffing A, Weiergraber O, Schwarten M, Hoffmann S, Willbold D
FEBS Lett
. 2024 Aug;
598(21):2656-2669.
PMID: 39160442
The human Atg8 family member GABARAP is involved in numerous autophagy-related and -unrelated processes. We recently observed that specifically the deficiency of GABARAP enhances epidermal growth factor receptor (EGFR) degradation...
9.
Dluhosch D, Kersten L, Schott-Verdugo S, Hoppen C, Schwarten M, Willbold D, et al.
Sci Rep
. 2024 Aug;
14(1):19099.
PMID: 39154065
Copper chaperones of the ATX1 family are found in a wide range of organisms where these essential soluble carriers strictly control the transport of monovalent copper across the cytoplasm to...
10.
Busley A, Gutierrez-Gutierrez O, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, et al.
Cell Rep
. 2024 Jul;
43(7):114448.
PMID: 39003740
Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset hypertrophic cardiomyopathy. In this study, we investigate the mechanistic consequences of a homozygous...