Philipp Leippe
Overview
Explore the profile of Philipp Leippe including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
263
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Recent Articles
1.
Fehrentz T, Amin E, Gorldt N, Strasdeit T, Moussavi-Torshizi S, Leippe P, et al.
Br J Pharmacol
. 2024 Nov;
182(5):1125-1142.
PMID: 39543799
Background And Purpose: Patients suffering from ischaemic heart disease and heart failure are at high risk of recurrent ventricular arrhythmias (VAs), eventually leading to sudden cardiac death. While high-voltage shocks...
2.
Cell-Specific Optical Control of AMPA Glutamate Receptors with a Photoswitchable Tethered Antagonist
Leippe P, Donthamsetti P, Ko T, Stanley C, Isacoff E, Trauner D
Angew Chem Int Ed Engl
. 2024 Aug;
63(49):e202411181.
PMID: 39189798
AMPA receptors (AMPARs) are the main drivers of excitatory glutamatergic transmission in the brain, central to synaptic plasticity, and are key drug targets. However, AMPARs are expressed in virtually every...
3.
Digles D, Ingles-Prieto A, Dvorak V, Mocking T, Goldmann U, Garofoli A, et al.
Front Pharmacol
. 2024 Jul;
15:1401599.
PMID: 39050757
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with...
4.
Hellweg L, Pfeifer M, Tarnawski M, Thing-Teoh S, Chang L, Bergner A, et al.
Cell Chem Biol
. 2024 May;
31(8):1529-1541.e12.
PMID: 38806058
Aspartate is crucial for nucleotide synthesis, ammonia detoxification, and maintaining redox balance via the malate-aspartate-shuttle (MAS). To disentangle these multiple roles of aspartate metabolism, tools are required that measure aspartate...
5.
Kosar M, Sykes D, Viray A, Vitale R, Sarott R, Ganzoni R, et al.
J Am Chem Soc
. 2023 Jul;
145(28):15094-15108.
PMID: 37401816
Pharmacological modulation of cannabinoid receptor type 2 (CBR) holds promise for the treatment of neuroinflammatory disorders, such as Alzheimer's disease. Despite the importance of CBR, its expression and downstream signaling...
6.
Dvorak V, Wiedmer T, Ingles-Prieto A, Altermatt P, Batoulis H, Barenz F, et al.
Front Pharmacol
. 2021 Aug;
12:722889.
PMID: 34447313
The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied....
7.
Hinnah K, Willems S, Morstein J, Heering J, Hartrampf F, Broichhagen J, et al.
J Med Chem
. 2020 Sep;
63(19):10908-10920.
PMID: 32886507
Photopharmacology aims at the optical control of protein activity using synthetic photoswitches. This approach has been recently expanded to nuclear hormone receptors with the introduction of "photohormones" for the retinoic...
8.
Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, Barbosa B, Girardi E, et al.
Nat Rev Drug Discov
. 2020 Apr;
19(7):429-430.
PMID: 32265506
No abstract available.
9.
Leippe P, Broichhagen J, Cailliau K, Mougel A, Morel M, Dissous C, et al.
Angew Chem Int Ed Engl
. 2019 Dec;
59(17):6720-6723.
PMID: 31872568
Receptor tyrosine kinases (RTKs) are key regulators of cellular functions in metazoans. In vertebrates, RTKs are mostly activated by polypeptides but are not naturally sensitive to amino acids or light....
10.
Maier M, Hull K, Reynders M, Matsuura B, Leippe P, Ko T, et al.
J Am Chem Soc
. 2019 Oct;
141(43):17295-17304.
PMID: 31584272
Azobenzenes are versatile photoswitches that have found widespread use in a variety of fields, ranging from photopharmacology to the material sciences. In addition to regular azobenzenes, the cyclic diazocines have...