Philip W Landfield
Overview
Explore the profile of Philip W Landfield including associated specialties, affiliations and a list of published articles.
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30
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2405
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Recent Articles
1.
Gant J, Kadish I, Chen K, Thibault O, Blalock E, Porter N, et al.
J Alzheimers Dis
. 2018 Nov;
66(4):1371-1378.
PMID: 30412490
Aging is the leading risk factor for idiopathic Alzheimer's disease (AD), indicating that normal aging processes promote AD and likely are present in the neurons in which AD pathogenesis originates....
2.
Gant J, Blalock E, Chen K, Kadish I, Thibault O, Porter N, et al.
J Neurosci
. 2017 Dec;
38(4):1030-1041.
PMID: 29255009
Hippocampal overexpression of FK506-binding protein 12.6/1b (), a negative regulator of ryanodine receptor Ca release, reverses aging-induced memory impairment and neuronal Ca dysregulation. Here, we tested the hypothesis that also...
3.
Gant J, Chen K, Kadish I, Blalock E, Thibault O, Porter N, et al.
J Neurosci
. 2015 Jul;
35(30):10878-87.
PMID: 26224869
Significance Statement: This paper reports critical tests of a novel hypothesis that proposes a molecular mechanism of unhealthy brain aging and possibly, Alzheimer's disease. For more than 30 years, evidence...
4.
Latimer C, Brewer L, Searcy J, Chen K, Popovic J, Kraner S, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(41):E4359-66.
PMID: 25267625
Vitamin D is an important calcium-regulating hormone with diverse functions in numerous tissues, including the brain. Increasing evidence suggests that vitamin D may play a role in maintaining cognitive function...
5.
Thibault O, Anderson K, DeMoll C, Brewer L, Landfield P, Porter N
Eur J Pharmacol
. 2013 Jul;
719(1-3):34-43.
PMID: 23872402
Recently it has become clear that conditions of insulin resistance/metabolic syndrome, obesity and diabetes, are linked with moderate cognitive impairment in normal aging and elevated risk of Alzheimer's disease. It...
6.
Chen K, Blalock E, Curran-Rauhut M, Kadish I, Blalock S, Brewer L, et al.
Endocrinology
. 2013 Jun;
154(8):2807-20.
PMID: 23736296
Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the long-standing hypothesis that chronic GC...
7.
Pancani T, Anderson K, Brewer L, Kadish I, DeMoll C, Landfield P, et al.
Neurobiol Aging
. 2013 Apr;
34(8):1977-87.
PMID: 23545425
The prevalence of obesity and type 2 diabetes increases with age. Despite this, few studies have examined these conditions simultaneously in aged animals, and fewer studies have measured the impact...
8.
Craft S, Foster T, Landfield P, Maier S, Resnick S, Yaffe K
J Gerontol A Biol Sci Med Sci
. 2012 May;
67(7):754-9.
PMID: 22570133
There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected...
9.
Searcy J, Phelps J, Pancani T, Kadish I, Popovic J, Anderson K, et al.
J Alzheimers Dis
. 2012 Apr;
30(4):943-61.
PMID: 22495349
Thiazolidinediones (TZDs) are agonists at peroxisome proliferator-activated gamma-type (PPAR-γ) receptors and are used clinically for the treatment of type 2 diabetes where they have been shown to reestablish insulin sensitivity,...
10.
Thibault O, Pancani T, Landfield P, Norris C
Biochim Biophys Acta
. 2012 Jan;
1822(4):546-9.
PMID: 22265986
Increased function of neuronal L-type voltage-sensitive Ca(2+) channels (L-VSCCs) is strongly linked to impaired memory and altered hippocampal synaptic plasticity in aged rats. However, no studies have directly assessed L-VSCC...