John C Gant
Overview
Explore the profile of John C Gant including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
17
Citations
838
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Weiss B, Gant J, Gant J, Lin R, Gollihue J, Kraner S, et al.
bioRxiv
. 2025 Feb;
PMID: 39896447
While cerebrovascular dysfunction and reactive astrocytosis are extensively characterized hallmarks of Alzheimer's disease (AD) and related dementias, the dynamic relationship between reactive astrocytes and cerebral vessels remains poorly understood. Here,...
2.
Sompol P, Gollihue J, Weiss B, Lin R, Case S, Kraner S, et al.
J Neurosci
. 2023 Feb;
43(10):1797-1813.
PMID: 36746627
Despite the indispensable role that astrocytes play in the neurovascular unit, few studies have investigated the functional impact of astrocyte signaling in cognitive decline and dementia related to vascular pathology....
3.
Ghoweri A, Ouillette L, Frazier H, Anderson K, Lin R, Gant J, et al.
J Alzheimers Dis
. 2020 Nov;
78(4):1419-1438.
PMID: 33164928
Background: In animal models and tissue preparations, calcium dyshomeostasis is a biomarker of aging and Alzheimer's disease that is associated with synaptic dysfunction, neuritic pruning, and dysregulated cellular processes. It...
4.
Ghoweri A, Gagolewicz P, Frazier H, Gant J, Andrew R, Bennett B, et al.
J Alzheimers Dis
. 2020 Sep;
77(4):1623-1637.
PMID: 32925058
Background: Dysregulated signaling in neurons and astrocytes participates in pathophysiological alterations seen in the Alzheimer's disease brain, including increases in amyloid-β, hyperphosphorylated tau, inflammation, calcium dysregulation, and oxidative stress. These...
5.
Gant J, Kadish I, Chen K, Thibault O, Blalock E, Porter N, et al.
J Alzheimers Dis
. 2018 Nov;
66(4):1371-1378.
PMID: 30412490
Aging is the leading risk factor for idiopathic Alzheimer's disease (AD), indicating that normal aging processes promote AD and likely are present in the neurons in which AD pathogenesis originates....
6.
Gant J, Blalock E, Chen K, Kadish I, Thibault O, Porter N, et al.
J Neurosci
. 2017 Dec;
38(4):1030-1041.
PMID: 29255009
Hippocampal overexpression of FK506-binding protein 12.6/1b (), a negative regulator of ryanodine receptor Ca release, reverses aging-induced memory impairment and neuronal Ca dysregulation. Here, we tested the hypothesis that also...
7.
Berkowitz B, Lenning J, Khetarpal N, Tran C, Wu J, Berri A, et al.
FASEB J
. 2017 Jun;
31(9):4179-4186.
PMID: 28592637
Hippocampus oxidative stress is considered pathogenic in neurodegenerative diseases, such as Alzheimer disease (AD), and in neurodevelopmental disorders, such as Angelman syndrome (AS). Yet clinical benefits of antioxidant treatment for...
8.
Frazier H, Maimaiti S, Anderson K, Brewer L, Gant J, Porter N, et al.
Biochem Biophys Res Commun
. 2016 Aug;
483(4):981-987.
PMID: 27553276
Neuroscientists studying normal brain aging, spinal cord injury, Alzheimer's disease (AD) and other neurodegenerative diseases have focused considerable effort on carefully characterizing intracellular perturbations in calcium dynamics or levels. At...
9.
Gant J, Chen K, Kadish I, Blalock E, Thibault O, Porter N, et al.
J Neurosci
. 2015 Jul;
35(30):10878-87.
PMID: 26224869
Significance Statement: This paper reports critical tests of a novel hypothesis that proposes a molecular mechanism of unhealthy brain aging and possibly, Alzheimer's disease. For more than 30 years, evidence...
10.
Maimaiti S, Anderson K, DeMoll C, Brewer L, Rauh B, Gant J, et al.
J Gerontol A Biol Sci Med Sci
. 2015 Feb;
71(1):30-9.
PMID: 25659889
Peripheral insulin resistance is a key component of metabolic syndrome associated with obesity, dyslipidemia, hypertension, and type 2 diabetes. While the impact of insulin resistance is well recognized in the...