Session III: Mechanisms of Age-related Cognitive Change and Targets for Intervention: Inflammatory, Oxidative, and Metabolic Processes

Overview

Journal J Gerontol A Biol Sci Med Sci

Specialty Geriatrics

Date 2012 May 10

PMID 22570133

Citations 35

Authors

Suzanne Craft

Thomas C Foster

Philip W Landfield

Steven F Maier

Susan M Resnick

Kristine Yaffe

Affiliations

Soon will be listed here.

Abstract

There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.

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