Olivier Thibault
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Explore the profile of Olivier Thibault including associated specialties, affiliations and a list of published articles.
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51
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1511
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Recent Articles
1.
Weiss B, Gant J, Gant J, Lin R, Gollihue J, Kraner S, et al.
bioRxiv
. 2025 Feb;
PMID: 39896447
While cerebrovascular dysfunction and reactive astrocytosis are extensively characterized hallmarks of Alzheimer's disease (AD) and related dementias, the dynamic relationship between reactive astrocytes and cerebral vessels remains poorly understood. Here,...
2.
Sims S, Frazier H, Case S, Lin R, Trosper J, Vekaria H, et al.
NPJ Metab Health Dis
. 2024 Nov;
2(1):33.
PMID: 39524535
Energy flow within cellular elements of the brain is a well-orchestrated, tightly regulated process, however, details underlying these functions at the single-cell level are still poorly understood. Studying hypometabolism in...
3.
Wu L, Wang F, Moncman C, Pandey M, Clarke H, Frazier H, et al.
Heliyon
. 2023 Oct;
9(10):e20384.
PMID: 37780758
Oligodendrocytes (OLs) generate lipid-rich myelin membranes that wrap axons to enable efficient transmission of electrical impulses. Using a knockout mouse model and high-resolution matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI)...
4.
Case S, Lin R, Thibault O
Aging Cell
. 2023 Jun;
22(8):e13898.
PMID: 37269157
Over the past 30 years, the calcium (Ca ) hypothesis of brain aging has provided clear evidence that hippocampal neuronal Ca dysregulation is a key biomarker of aging. Age-dependent Ca...
5.
Sompol P, Gollihue J, Weiss B, Lin R, Case S, Kraner S, et al.
J Neurosci
. 2023 Feb;
43(10):1797-1813.
PMID: 36746627
Despite the indispensable role that astrocytes play in the neurovascular unit, few studies have investigated the functional impact of astrocyte signaling in cognitive decline and dementia related to vascular pathology....
6.
Case S, Frazier H, Anderson K, Lin R, Thibault O
Biomedicines
. 2022 Aug;
10(8).
PMID: 36009470
Insulin resistance, which manifests as a reduction of insulin receptor signaling, is known to correlate with pathological changes in peripheral tissues as well as in the brain. Central insulin resistance...
7.
Lin R, Frazier H, Anderson K, Case S, Ghoweri A, Thibault O
Aging Cell
. 2022 Jun;
21(7):e13661.
PMID: 35717599
Neuronal hippocampal Ca dysregulation is a critical component of cognitive decline in brain aging and Alzheimer's disease and is suggested to impact communication and excitability through the activation of a...
8.
Craven R, Frazier H, Thibault O
Brain Res
. 2021 Dec;
1776:147747.
PMID: 34864044
Glucose uptake in the brain is critically important to brain health. Using two widely used cell line model systems, we have found that siramesine, a lysosomotropic agent and ligand for...
9.
Dalmasso C, Leachman J, Ghuneim S, Ahmed N, Schneider E, Thibault O, et al.
Hypertension
. 2021 Oct;
78(5):1434-1449.
PMID: 34601958
[Figure: see text].
10.
Ghoweri A, Ouillette L, Frazier H, Anderson K, Lin R, Gant J, et al.
J Alzheimers Dis
. 2020 Nov;
78(4):1419-1438.
PMID: 33164928
Background: In animal models and tissue preparations, calcium dyshomeostasis is a biomarker of aging and Alzheimer's disease that is associated with synaptic dysfunction, neuritic pruning, and dysregulated cellular processes. It...