Philip S Insel
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Explore the profile of Philip S Insel including associated specialties, affiliations and a list of published articles.
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76
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2999
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Recent Articles
11.
Young C, Johns E, Kennedy G, Belloy M, Insel P, Greicius M, et al.
Mol Neurodegener
. 2023 Jan;
18(1):1.
PMID: 36597122
Background: APOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of APOE on tau aggregation are reported in animal and human cell models. The degree to...
12.
Hansson O, Kumar A, Janelidze S, Stomrud E, Insel P, Blennow K, et al.
EMBO Mol Med
. 2022 Dec;
15(1):e16359.
PMID: 36504281
Studies of the genetic regulation of cerebrospinal fluid (CSF) proteins may reveal pathways for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 participants from the BioFINDER...
13.
Mormino E, Insel P
Alzheimers Dement (Amst)
. 2022 Sep;
14(1):e12348.
PMID: 36051175
No abstract available.
14.
Insel P, Young C, Aisen P, Johnson K, Sperling R, Mormino E, et al.
Brain
. 2022 Aug;
146(2):700-711.
PMID: 35962782
Rates of tau accumulation in cognitively unimpaired older adults are subtle, with magnitude and spatial patterns varying in recent reports. Regional accumulation also likely varies in the degree to which...
15.
Kassel M, Rhodes E, Insel P, Woodworth K, Garrison-Diehn C, Satre D, et al.
Int J Geriatr Psychiatry
. 2022 Jul;
37(8).
PMID: 35822633
Objectives: Late Life Depression (LLD) is associated with persistent cognitive dysfunction even after depression symptoms improve. The present study was designed to examine cognitive outcomes associated with the pattern of...
16.
Insel P, Mohlenhoff B, Neylan T, Krystal A, Mackin R
JAMA Netw Open
. 2021 Jul;
4(7):e2117573.
PMID: 34297074
Importance: Disrupted sleep commonly occurs with progressing neurodegenerative disease. Large, well-characterized neuroimaging studies of cognitively unimpaired adults are warranted to clarify the magnitude and onset of the association between sleep...
17.
Mackin R, Rhodes E, Insel P, Nosheny R, Finley S, Ashford M, et al.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn
. 2021 Jun;
29(5):867-881.
PMID: 34139954
Introduction: The objective of this study is to evaluate the reliability and validity of the ReVeRe word list recall test (RWLRT), which uses speech recognition, when administered remotely and unsupervised....
18.
Lopes Alves I, Heeman F, Collij L, Salvado G, Tolboom N, Vilor-Tejedor N, et al.
Alzheimers Res Ther
. 2021 Apr;
13(1):82.
PMID: 33875021
Background: Detecting subtle-to-moderate biomarker changes such as those in amyloid PET imaging becomes increasingly relevant in the context of primary and secondary prevention of Alzheimer's disease (AD). This work aimed...
19.
Berron D, Vogel J, Insel P, Pereira J, Xie L, Wisse L, et al.
Brain
. 2021 Mar;
144(9):2771-2783.
PMID: 33725124
In Alzheimer's disease, post-mortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps...
20.
Rhodes E, Insel P, Butters M, Morin R, Bickford D, Tosun D, et al.
J Alzheimers Dis
. 2021 Mar;
80(3):991-1002.
PMID: 33682706
Background: Cognitive impairment (CI) is a key feature of late life depression (LLD), but the contribution of underlying neurodegenerative pathology remains unclear. Objective: To evaluate cognitive dysfunction in LLD relative...