Uncertainties in the PET Defined A-/T+ Subtype

Overview

Journal Alzheimers Dement (Amst)

Date 2022 Sep 2

PMID 36051175

Authors

Elizabeth C Mormino

Philip S Insel

Affiliations

Soon will be listed here.

References

Jack Jr C, Bennett D, Blennow K, Carrillo M, Dunn B, Budd Haeberlein S . NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018; 14(4):535-562. PMC: 5958625. DOI: 10.1016/j.jalz.2018.02.018. View

Nelson P, Alafuzoff I, Bigio E, Bouras C, Braak H, Cairns N . Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012; 71(5):362-81. PMC: 3560290. DOI: 10.1097/NEN.0b013e31825018f7. View

Chhatwal J, Schultz S, McDade E, Schultz A, Liu L, Hanseeuw B . Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study. Lancet Neurol. 2022; 21(2):140-152. PMC: 8956209. DOI: 10.1016/S1474-4422(21)00375-6. View

Krishnadas N, Dore V, Laws S, Porter T, Lamb F, Bozinovski S . Exploring discordant low amyloid beta and high neocortical tau positron emission tomography cases. Alzheimers Dement (Amst). 2022; 14(1):e12326. PMC: 9413469. DOI: 10.1002/dad2.12326. View

Braak H, Thal D, Ghebremedhin E, Del Tredici K . Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol. 2011; 70(11):960-9. DOI: 10.1097/NEN.0b013e318232a379. View

Crary J, Trojanowski J, Schneider J, Abisambra J, Abner E, Alafuzoff I . Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. 2014; 128(6):755-66. PMC: 4257842. DOI: 10.1007/s00401-014-1349-0. View

Nakamura A, Kaneko N, Villemagne V, Kato T, Doecke J, Dore V . High performance plasma amyloid-β biomarkers for Alzheimer's disease. Nature. 2018; 554(7691):249-254. DOI: 10.1038/nature25456. View

Klunk W, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt D . Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 2004; 55(3):306-19. DOI: 10.1002/ana.20009. View

Makaretz S, Quimby M, Collins J, Makris N, McGinnis S, Schultz A . Flortaucipir tau PET imaging in semantic variant primary progressive aphasia. J Neurol Neurosurg Psychiatry. 2017; 89(10):1024-1031. PMC: 5964045. DOI: 10.1136/jnnp-2017-316409. View

10.

Lockhart S, Ayakta N, Winer J, La Joie R, Rabinovici G, Jagust W . Elevated F-AV-1451 PET tracer uptake detected in incidental imaging findings. Neurology. 2017; 88(11):1095-1097. PMC: 5384840. DOI: 10.1212/WNL.0000000000003724. View

11.

Villemagne V, Burnham S, Bourgeat P, Brown B, Ellis K, Salvado O . Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. Lancet Neurol. 2013; 12(4):357-67. DOI: 10.1016/S1474-4422(13)70044-9. View

12.

La Joie R, Ayakta N, Seeley W, Borys E, Boxer A, DeCarli C . Multisite study of the relationships between antemortem [C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimers Dement. 2018; 15(2):205-216. PMC: 6368897. DOI: 10.1016/j.jalz.2018.09.001. View

13.

Thijssen E, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A . Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. Lancet Neurol. 2021; 20(9):739-752. PMC: 8711249. DOI: 10.1016/S1474-4422(21)00214-3. View

14.

Salvado G, Molinuevo J, Brugulat-Serrat A, Falcon C, Grau-Rivera O, Suarez-Calvet M . Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers. Alzheimers Res Ther. 2019; 11(1):27. PMC: 6429814. DOI: 10.1186/s13195-019-0478-z. View

15.

Dore V, Doecke J, Saad Z, Triana-Baltzer G, Slemmon R, Krishnadas N . Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum. Alzheimers Dement (Amst). 2022; 14(1):e12307. PMC: 8984092. DOI: 10.1002/dad2.12307. View

16.

Jagust W, Landau S . Temporal Dynamics of β-Amyloid Accumulation in Aging and Alzheimer Disease. Neurology. 2021; 96(9):e1347-e1357. PMC: 8055327. DOI: 10.1212/WNL.0000000000011524. View