Philip J OConnell
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Explore the profile of Philip J OConnell including associated specialties, affiliations and a list of published articles.
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133
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3117
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Recent Articles
1.
LILRB3 genetic variation is associated with kidney transplant failure in African American recipients
Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, et al.
Nat Med
. 2025 Mar;
PMID: 40065170
African American (AA) kidney transplant recipients exhibit a higher rate of graft loss compared with other racial and ethnic populations, highlighting the need to identify causative factors. Here, in the...
2.
Robertson H, Kim H, Li J, Robertson N, Robertson P, Jimenez-Vera E, et al.
Nat Med
. 2024 Jun;
30(12):3748-3757.
PMID: 38890530
The pathogenesis of allograft (dys)function has been increasingly studied using 'omics'-based technologies, but the focus on individual organs has created knowledge gaps that neither unify nor distinguish pathological mechanisms across...
3.
Pan Z, El Sharkway R, Bayoumi A, Metwally M, Gloss B, Brink R, et al.
Sci Transl Med
. 2024 Apr;
16(741):eadj0133.
PMID: 38569018
Transforming growth factor-β (TGFβ) drives fibrosis and disease progression in a number of chronic disorders, but targeting this ubiquitously expressed cytokine may not yield a viable and safe antifibrotic therapy....
4.
Zhao Y, Nicholson L, Wang H, Qian Y, Hawthorne W, Jimenez-Vera E, et al.
JCI Insight
. 2024 Mar;
9(6).
PMID: 38516885
CD4+Foxp3+ regulatory T cells (Tregs) play an essential role in suppressing transplant rejection, but their role within the graft and heterogeneity in tolerance are poorly understood. Here, we compared phenotypic...
5.
Ma X, Cao L, Raneri M, Wang H, Cao Q, Zhao Y, et al.
JCI Insight
. 2023 Oct;
8(23).
PMID: 37874660
Regulatory T cells (Tregs) have potential for the treatment of autoimmune diseases and graft rejection. Antigen specificity and functional stability are considered critical for their therapeutic efficacy. In this study,...
6.
Sun Z, Zhang Z, Banu K, Gibson I, Colvin R, Yi Z, et al.
J Clin Invest
. 2023 Sep;
133(21).
PMID: 37676733
Donor-recipient (D-R) mismatches outside of human leukocyte antigens (HLAs) contribute to kidney allograft loss, but the mechanisms remain unclear, specifically for intronic mismatches. We quantified non-HLA mismatches at variant-, gene-,...
7.
Collins M, Fahim M, Pascoe E, Hawley C, Johnson D, Varghese J, et al.
Lancet
. 2023 Jun;
402(10396):105-117.
PMID: 37343576
Background: Delayed graft function (DGF) is a major adverse complication of deceased donor kidney transplantation. Intravenous fluids are routinely given to patients receiving a transplant to maintain intravascular volume and...
8.
Rogers N, Zammit N, Nguyen-Ngo D, Souilmi Y, Minhas N, Meijles D, et al.
Kidney Int
. 2023 Apr;
103(6):1105-1119.
PMID: 37097268
Nuclear factor κB (NF-κB) activation is a deleterious molecular mechanism that drives acute kidney injury (AKI) and manifests in transplanted kidneys as delayed graft function. The TNFAIP3 gene encodes A20,...
9.
Rojas-Canales D, Walters S, Penko D, Cultrone D, Bailey J, Chtanova T, et al.
Diabetes
. 2023 Mar;
72(6):758-768.
PMID: 36929171
Article Highlights: Human and porcine pancreatic islets were transplanted into a fully vascularized biodegradable temporizing matrix (Novosorb) that creates a unique intracutaneous site outside of the liver in a large-animal...
10.
Collins M, Fahim M, Pascoe E, Hawley C, Johnson D, Varghese J, et al.
Transplant Direct
. 2022 Dec;
8(12):e1399.
PMID: 36479278
Methods: We compared the characteristics of BEST-Fluids participants with those of a contemporary cohort of deceased donor kidney transplant recipients in Australia and New Zealand using data from the Australia...