Philip J OConnell
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Explore the profile of Philip J OConnell including associated specialties, affiliations and a list of published articles.
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133
Citations
3117
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Recent Articles
11.
Dominguez-Gil B, Ascher N, Fadhil R, Muller E, Cantarovich M, Ahn C, et al.
Transplantation
. 2022 Oct;
106(11):2111-2117.
PMID: 36279558
Background: Transplant therapy is considered the best and often the only available treatment for thousands of patients with organ failure that results from communicable and noncommunicable diseases. The number of...
12.
Hu M, Hawthorne W, Yi S, OConnell P
Front Immunol
. 2022 Jul;
13:893985.
PMID: 35874735
Porcine islets surviving the acute injury caused by humoral rejection and IBMIR will be subjected to cellular xenograft rejection, which is predominately mediated by CD4 T cells and is characterised...
13.
Hawthorne W, Salvaris E, Chew Y, Burns H, Hawkes J, Barlow H, et al.
Front Immunol
. 2022 Jul;
13:898948.
PMID: 35784286
Xenotransplantation using porcine donors is rapidly approaching clinical applicability as an alternative therapy for treatment of many end-stage diseases including type 1 diabetes. Porcine neonatal islet cell clusters (NICC) have...
14.
Yi Z, Salem F, Menon M, Keung K, Xi C, Hultin S, et al.
Kidney Int
. 2021 Nov;
101(2):288-298.
PMID: 34757124
Interstitial fibrosis, tubular atrophy, and inflammation are major contributors to kidney allograft failure. Here we sought an objective, quantitative pathological assessment of these lesions to improve predictive utility and constructed...
15.
Hu M, Rogers N, Li J, Zhang G, Wang Y, Shaw K, et al.
Front Immunol
. 2021 Sep;
12:717594.
PMID: 34512640
Kidney transplantation is the most common solid organ transplant and the best current therapy for end-stage kidney failure. However, with standard immunosuppression, most transplants develop chronic dysfunction or fail, much...
16.
Zhang Z, Sun Z, Fu J, Lin Q, Banu K, Chauhan K, et al.
J Clin Invest
. 2021 Sep;
131(22).
PMID: 34499625
Apolipoprotein L1 (APOL1) risk alleles in donor kidneys associate with graft loss, but whether recipient risk allele expression affects transplant outcomes is unclear. To test whether recipient APOL1 risk alleles...
17.
Mudiayi D, Shojai S, Okpechi I, Christie E, Wen K, Kamaleldin M, et al.
Transplantation
. 2021 Sep;
106(6):1113-1122.
PMID: 34495014
Background: Kidney transplantation (KT) is the optimal treatment for kidney failure and is associated with better quality of life and survival relative to dialysis. However, knowledge of the current capacity...
18.
Hawthorne W, Davies S, Mun H, Chew Y, Williams L, Anderson P, et al.
Metabolites
. 2021 Jul;
11(6).
PMID: 34198953
Cold ischemia and hence travel time can adversely affect outcomes of islet isolation. The aim of this study was to compare the isolation and transplant outcomes of donor pancreata according...
19.
Adhikary S, Cuthbertson P, Nicholson L, Bird K, Sligar C, Hu M, et al.
Immunology
. 2021 May;
164(2):332-347.
PMID: 34021907
Graft-versus-host disease (GVHD) is a major complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT) that develops when donor T cells in the graft become reactive against the host. Post-transplant cyclophosphamide...
20.
Wong W, Joglekar M, Saini V, Jiang G, Dong C, Chaitarvornkit A, et al.
iScience
. 2021 May;
24(4):102379.
PMID: 33981968
Dicer knockout mouse models demonstrated a key role for microRNAs in pancreatic β-cell function. Studies to identify specific microRNA(s) associated with human (pro-)endocrine gene expression are needed. We profiled microRNAs...