Philip E Brandish
Overview
Explore the profile of Philip E Brandish including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
23
Citations
496
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Xiang H, Pan Y, Sze M, Wlodarska M, Li L, van de Mark K, et al.
Cancer Res
. 2024 Feb;
84(9):1410-1425.
PMID: 38335304
Significance: NOTCH3 signaling activates tumor-associated mesenchymal cells, increases collagen production, and augments cell invasion in lung adenocarcinoma, suggesting its critical role in remodeling tumor stroma.
2.
Yuan H, Jin L, Xiang H, Bhattacharya A, Brandish P, Baltus G, et al.
Oncotarget
. 2022 Dec;
13:1350-1358.
PMID: 36537914
One of the central challenges for cancer therapy is the identification of factors in the tumor microenvironment that increase tumor progression and immune tolerance. In breast cancer, fibrosis is a...
3.
Singh L, Muise E, Bhattacharya A, Grein J, Javaid S, Stivers P, et al.
Mol Cancer Res
. 2020 Dec;
19(4):702-716.
PMID: 33372059
Myeloid-derived suppressor cells (MDSC) are immature myeloid cells that accumulate in the tumor microenvironment (TME). MDSCs have been shown to dampen antitumor immune responses and promote tumor growth; however, the...
4.
Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Babu Boga S, et al.
Bioorg Med Chem Lett
. 2020 Aug;
30(17):127390.
PMID: 32738973
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B...
5.
Xiang H, Ramil C, Hai J, Zhang C, Wang H, Watkins A, et al.
Cancer Immunol Res
. 2020 Feb;
8(4):436-450.
PMID: 32075803
Cancer-associated fibroblasts (CAF) represent a functionally heterogeneous population of activated fibroblasts that constitutes a major component of tumor stroma. Although CAFs have been shown to promote tumor growth and mediate...
6.
Brandish P, Palmieri A, Antonenko S, Beaumont M, Benso L, Cancilla M, et al.
Bioconjug Chem
. 2018 Jun;
29(7):2357-2369.
PMID: 29923706
Glucocorticoids (GCs) are excellent anti-inflammatory drugs but are dose-limited by on-target toxicity. We sought to solve this problem by delivering GCs to immune cells with antibody-drug conjugates (ADCs) using antibodies...
7.
Babu Boga S, Alhassan A, Liu J, Guiadeen D, Krikorian A, Gao X, et al.
Bioorg Med Chem Lett
. 2017 Jul;
27(16):3939-3943.
PMID: 28720503
8-Amino-imidazo[1,5-a]pyrazine-based Bruton's tyrosine kinase (BTK) inhibitors, such as 6, exhibited potent inhibition of BTK but required improvements in both kinase and hERG selectivity (Liu et al., 2016; Gao et al.,...
8.
Gao X, Wang J, Liu J, Guiadeen D, Krikorian A, Babu Boga S, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(6):1471-1477.
PMID: 28254166
We report the design and synthesis of a series of novel Bruton's Tyrosine Kinase (BTK) inhibitors with a carboxylic acid moiety in the ribose pocket. This series of compounds has...
9.
Kern J, Dooney D, Zhang R, Liang L, Brandish P, Cheng M, et al.
Bioconjug Chem
. 2016 Jul;
27(9):2081-8.
PMID: 27469406
In an effort to examine the utility of antibody-drug conjugates (ADCs) beyond oncology indications, a novel phosphate bridged Cathepsin B sensitive linker was developed to enable the targeted delivery of...
10.
Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Babu Boga S, et al.
ACS Med Chem Lett
. 2016 Mar;
7(2):198-203.
PMID: 26985298
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B...