Arto Krikorian
Overview
Explore the profile of Arto Krikorian including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
24
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Recent Articles
1.
Liu J, Shao P, Guiadeen D, Krikorian A, Sun W, Deng Q, et al.
Bioorg Med Chem Lett
. 2020 Nov;
32:127668.
PMID: 33161125
Cholesteryl ester transfer protein (CETP) inhibitors reduce the transfer of cholesteryl esters from the high-density lipoprotein (HDL-C) to apolipoprotein such as VLDL/LDL, with exchange of triglycerides. Thus, this inhibition increases...
2.
Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Babu Boga S, et al.
Bioorg Med Chem Lett
. 2020 Aug;
30(17):127390.
PMID: 32738973
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B...
3.
Yu Y, Wu Z, Shi Z, He S, Lai Z, Cernak T, et al.
Bioorg Med Chem Lett
. 2019 Apr;
29(11):1380-1385.
PMID: 30952592
The parallel medicinal chemistry (PMC) was effectively applied to accelerate the optimization of diacylglycerol O-acyltransferase I (DGAT-1) inhibitors. Through a highly collaborative and iterative library design, synthesis and testing, a...
4.
Babu Boga S, Alhassan A, Liu J, Guiadeen D, Krikorian A, Gao X, et al.
Bioorg Med Chem Lett
. 2017 Jul;
27(16):3939-3943.
PMID: 28720503
8-Amino-imidazo[1,5-a]pyrazine-based Bruton's tyrosine kinase (BTK) inhibitors, such as 6, exhibited potent inhibition of BTK but required improvements in both kinase and hERG selectivity (Liu et al., 2016; Gao et al.,...
5.
Gao X, Wang J, Liu J, Guiadeen D, Krikorian A, Babu Boga S, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(6):1471-1477.
PMID: 28254166
We report the design and synthesis of a series of novel Bruton's Tyrosine Kinase (BTK) inhibitors with a carboxylic acid moiety in the ribose pocket. This series of compounds has...
6.
Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Babu Boga S, et al.
ACS Med Chem Lett
. 2016 Mar;
7(2):198-203.
PMID: 26985298
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B...