Younong Yu
Overview
Explore the profile of Younong Yu including associated specialties, affiliations and a list of published articles.
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24
Citations
205
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Recent Articles
1.
Tyagarajan S, Andrews C, Beshore D, Buevich A, Curran P, Dandliker P, et al.
ACS Med Chem Lett
. 2024 Oct;
15(10):1787-1794.
PMID: 39411537
The science of drug discovery involves multiparameter optimization of molecular structures through iterative design-make-test cycles. For medicinal chemistry library synthesis, traditional workflows involve the isolation of each individual compound, gravimetric...
2.
Yu W, Liu J, Clausen D, Yu Y, Duffy J, Wang M, et al.
J Med Chem
. 2021 Apr;
64(8):4709-4729.
PMID: 33797924
We describe the discovery of histone deacetylase (HDACs) 1, 2, and 3 inhibitors with ethyl ketone as the zinc-binding group. These HDACs 1, 2, and 3 inhibitors have good enzymatic...
3.
Dykstra K, Streckfuss E, Liu M, Liu J, Yu Y, Wang M, et al.
ACS Med Chem Lett
. 2021 Mar;
12(3):337-342.
PMID: 33738059
An integrated workflow has been established that enables the synthesis, purification, and subsequent biological testing of compound libraries on a microgram scale. This approach utilizes mass directed preparative HPLC in...
4.
Liu J, Yu Y, Kelly J, Sha D, Alhassan A, Yu W, et al.
ACS Med Chem Lett
. 2020 Dec;
11(12):2476-2483.
PMID: 33335670
The selectivity of histone deacetylase inhibitors (HDACis) is greatly impacted by the zinc binding groups. In an effort to search for novel zinc binding groups, we applied a parallel medicinal...
5.
Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Babu Boga S, et al.
Bioorg Med Chem Lett
. 2020 Aug;
30(17):127390.
PMID: 32738973
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B...
6.
Liu J, Kelly J, Yu W, Clausen D, Yu Y, Kim H, et al.
ACS Med Chem Lett
. 2020 Jul;
11(7):1476-1483.
PMID: 32676157
HIV persistence in latently infected, resting CD4 T cells is broadly considered a barrier to eradicate HIV. Activation of the provirus using latency-reversing agents (LRAs) followed by immune-mediated clearance to...
7.
Yu W, Liu J, Yu Y, Zhang V, Clausen D, Kelly J, et al.
Bioorg Med Chem Lett
. 2020 Apr;
30(13):127197.
PMID: 32331932
A novel series of ethyl ketone based HDACs 1, 2, and 3 selective inhibitors have been identified with good enzymatic and cellular activity and high selectivity over HDACs 6 and...
8.
Yu Y, Zhang L, Buevich A, Li G, Tang H, Vachal P, et al.
J Am Chem Soc
. 2018 May;
140(22):6797-6800.
PMID: 29762027
Targeting tryptophan is a promising strategy to achieve high levels of selectivity for peptide or protein modification. A chemoselective peptide modification method via photocatalytic tryptophan β-position conjugation has been discovered....
9.
Babu Boga S, Alhassan A, Liu J, Guiadeen D, Krikorian A, Gao X, et al.
Bioorg Med Chem Lett
. 2017 Jul;
27(16):3939-3943.
PMID: 28720503
8-Amino-imidazo[1,5-a]pyrazine-based Bruton's tyrosine kinase (BTK) inhibitors, such as 6, exhibited potent inhibition of BTK but required improvements in both kinase and hERG selectivity (Liu et al., 2016; Gao et al.,...
10.
Gao X, Wang J, Liu J, Guiadeen D, Krikorian A, Babu Boga S, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(6):1471-1477.
PMID: 28254166
We report the design and synthesis of a series of novel Bruton's Tyrosine Kinase (BTK) inhibitors with a carboxylic acid moiety in the ribose pocket. This series of compounds has...