Peter W Stacpoole
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Explore the profile of Peter W Stacpoole including associated specialties, affiliations and a list of published articles.
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103
Citations
2480
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Recent Articles
1.
Stacpoole P, Dirain C
Mol Genet Metab
. 2024 Jul;
143(1-2):108540.
PMID: 39067348
The pyruvate dehydrogenase complex (PDC) is remarkable for its size and structure as well as for its physiological and pathological importance. Its canonical location is in the mitochondrial matrix, where...
2.
Stacpoole P
Biochem Pharmacol
. 2023 Sep;
217:115818.
PMID: 37742772
Herein I summarize the physiological chemistry and pharmacology of the bifunctional enzyme glutathione transferase zeta 1 (GSTZ1)/ maleylacetoacetate isomerase (MAAI) relevant to human physiology, drug metabolism and disease. MAAI is...
3.
Kamson D, Chinnasamy V, Grossman S, Bettegowda C, Barker P, Stacpoole P, et al.
Front Oncol
. 2023 Apr;
13:1077461.
PMID: 37007074
The adverse effects of lactic acidosis in the cancer microenvironment have been increasingly recognized. Dichloroacetate (DCA) is an orally bioavailable, blood brain barrier penetrable drug that has been extensively studied...
4.
Stacpoole P, McCall C
Mitochondrion
. 2023 Mar;
70:59-102.
PMID: 36863425
Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi-component megacomplexes provide a crucial mechanistic link between cytoplasmic...
5.
McCall C, Zhu X, Zabalawi M, Long D, Quinn M, Yoza B, et al.
J Leukoc Biol
. 2022 Jul;
112(6):1509-1514.
PMID: 35866365
Balancing high energy-consuming danger resistance and low energy supply of disease tolerance is a universal survival principle that often fails during sepsis. Our research supports the concept that sepsis phosphorylates...
6.
Oh T, Zabalawi M, Jain S, Long D, Stacpoole P, McCall C, et al.
JCI Insight
. 2022 Jun;
7(12).
PMID: 35730570
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to an infection. The metabolic aberrations associated with sepsis underly an acute and organism-wide hyperinflammatory response and multiple organ...
7.
Joseph S, Li M, Zhang S, Horne L, Stacpoole P, Wohlgemuth S, et al.
Am J Physiol Regul Integr Comp Physiol
. 2021 Dec;
322(1):R83-R98.
PMID: 34851727
Previous studies in our laboratory have suggested that the increase in stillbirth in pregnancies complicated by chronic maternal stress or hypercortisolemia is associated with cardiac dysfunction in late stages of...
8.
Joseph S, Sharma A, Horne L, Wood C, Langaee T, James M, et al.
Drug Metab Dispos
. 2021 Apr;
49(6):451-458.
PMID: 33811107
Sodium dichloroacetate (DCA) is an investigational drug that shows promise in the treatment of acquired and congenital mitochondrial diseases, including myocardial ischemia and failure. DCA increases glucose utilization and decreases...
9.
Mainali R, Zabalawi M, Long D, Buechler N, Quillen E, Key C, et al.
Elife
. 2021 Feb;
10.
PMID: 33616039
Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. While metabolic tissues such as the liver are subjected to damage during sepsis, how their...
10.
Squirewell E, Smeltz M, Rowland-Faux L, Horne L, Stacpoole P, James M
Drug Metab Dispos
. 2020 Sep;
48(11):1217-1223.
PMID: 32873593
Glutathione transferase zeta 1 (GSTZ1), expressed in liver and several extrahepatic tissues, catalyzes dechlorination of dichloroacetate (DCA) to glyoxylate. DCA inactivates GSTZ1, leading to autoinhibition of its metabolism. DCA is...