Albert L Shroads
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Explore the profile of Albert L Shroads including associated specialties, affiliations and a list of published articles.
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12
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Recent Articles
1.
Shroads A, Coats B, Langaee T, Shuster J, Stacpoole P
Drug Metab Pers Ther
. 2014 Oct;
30(1):49-55.
PMID: 25283137
Background: Chloral hydrate (CH), a sedative and metabolite of the environmental contaminant trichloroethylene, is metabolized to trichloroacetic acid, trichloroethanol, and possibly dichloroacetate (DCA). DCA is further metabolized by glutathione transferase...
2.
Abdelmalak M, Lew A, Ramezani R, Shroads A, Coats B, Langaee T, et al.
Mol Genet Metab
. 2013 Apr;
109(2):139-43.
PMID: 23611579
We followed 8 patients (4 males) with biochemically and/or molecular genetically proven deficiencies of the E1α subunit of the pyruvate dehydrogenase complex (PDC; 3 patients) or respiratory chain complexes I...
3.
Shroads A, Langaee T, Coats B, Kurtz T, Bullock J, Weithorn D, et al.
J Clin Pharmacol
. 2011 Jun;
52(6):837-49.
PMID: 21642471
Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic...
4.
Calcutt N, Lopez V, Bautista A, Mizisin L, Torres B, Shroads A, et al.
J Neuropathol Exp Neurol
. 2009 Aug;
68(9):985-93.
PMID: 19680144
The use of dichloroacetate (DCA) for treating patients with mitochondrial diseases is limited by the induction of peripheral neuropathy. The mechanisms of DCA-induced neuropathy are not known. Oral DCA treatment...
5.
Felitsyn N, McLeod C, Shroads A, Stacpoole P, Notterpek L
J Neurochem
. 2008 Jul;
106(5):2068-79.
PMID: 18665889
Delta-aminolevulinic acid (delta-ALA) is a heme precursor implicated in neurological complications associated with porphyria and tyrosinemia type I. Delta-ALA is also elevated in the urine of animals and patients treated...
6.
Shroads A, Guo X, Dixit V, Liu H, James M, Stacpoole P
J Pharmacol Exp Ther
. 2007 Dec;
324(3):1163-71.
PMID: 18096758
Dichloroacetate (DCA) is an investigational drug for certain metabolic diseases. It is biotransformed principally by the zeta-1 family isoform of glutathione transferase (GSTz1), also known as maleylacetoacetate isomerase (MAAI), which...
7.
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children
Stacpoole P, Kerr D, Barnes C, Bunch S, Carney P, Fennell E, et al.
Pediatrics
. 2006 May;
117(5):1519-31.
PMID: 16651305
Objective: Open-label studies indicate that oral dichloroacetate (DCA) may be effective in treating patients with congenital lactic acidosis. We tested this hypothesis by conducting the first double-blind, randomized, control trial...
8.
Langlois C, Jorquera R, Finegold M, Shroads A, Stacpoole P, Tanguay R
Biochem Pharmacol
. 2006 Apr;
71(11):1648-61.
PMID: 16581029
Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disease severely affecting liver and kidney and is caused by a deficiency in fumarylacetoacetate hydrolase (FAH). Administration of 2-(2-nitro-4-trifluoro-methylbenzyol)-1,3 cyclohexanedione (NTBC)...
9.
Guo X, Dixit V, Liu H, Shroads A, Henderson G, James M, et al.
Drug Metab Dispos
. 2005 Oct;
34(1):36-42.
PMID: 16199472
Dichloroacetate (DCA) is an investigational drug for certain metabolic disorders, a by-product of water chlorination and a metabolite of certain industrial solvents and drugs. DCA is biotransformed to glyoxylate by...
10.
Shroads A, Henderson G, Cheung J, James M, Stacpoole P
J Chromatogr B Analyt Technol Biomed Life Sci
. 2004 Jul;
808(2):153-61.
PMID: 15261808
Tyrosine and many of its catabolites play significant roles in the in the toxicity associated with acquired and congenital forms of hypertyrosinemia. We now report a specific and sensitive GC/MS...