George N Henderson
Overview
Explore the profile of George N Henderson including associated specialties, affiliations and a list of published articles.
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20
Citations
678
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Recent Articles
1.
Imaram W, Gersch C, Kim K, Johnson R, Henderson G, Angerhofer A
Free Radic Biol Med
. 2010 Apr;
49(2):275-81.
PMID: 20406679
Peroxynitrite is a reactive oxidant produced in vivo in response to oxidative and other stress by the diffusion-limited reaction of nitric oxide and superoxide. This article is focused on the...
2.
Kim K, Henderson G, Ouyang X, Frye R, Sautin Y, Feig D, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2009 Jun;
877(22):2032-8.
PMID: 19520625
Uric acid (UA) is known to be a major biological antioxidant in plasma. However, there is a strong correlation between UA levels and cardiovascular risk. Recent studies suggest that in...
3.
Gersch C, Palii S, Imaram W, Kim K, Karumanchi S, Angerhofer A, et al.
Nucleosides Nucleotides Nucleic Acids
. 2009 Feb;
28(2):118-49.
PMID: 19219741
Hyperuricemia is associated with hypertension, metabolic syndrome, preeclampsia, cardio-vascular disease and renal disease, all conditions associated with oxidative stress. We hypothesized that uric acid, a known antioxidant, might become prooxidative...
4.
Cirillo P, Gersch M, Mu W, Scherer P, Kim K, Gesualdo L, et al.
J Am Soc Nephrol
. 2009 Jan;
20(3):545-53.
PMID: 19158351
Increased consumption of fructose may play an important role in the epidemic of metabolic syndrome and may presage the development of diabetes, cardiovascular disease, and chronic kidney disease. Once in...
5.
Kim K, Henderson G, Frye R, Galloway C, Brown N, Segal M, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2008 Dec;
877(1-2):65-70.
PMID: 19081307
Uric acid (UA) can be directly converted to allantoin enzymatically by uricase in most mammals except humans or by reaction with superoxide. UA can react directly with nitric oxide to...
6.
Gersch C, Palii S, Kim K, Angerhofer A, Johnson R, Henderson G
Nucleosides Nucleotides Nucleic Acids
. 2008 Aug;
27(8):967-78.
PMID: 18696365
The 1980 identification of nitric oxide (NO) as an endothelial cell-derived relaxing factor resulted in an unprecedented biomedical research of NO and established NO as one of the most important...
7.
Johnson R, Gaucher E, Sautin Y, Henderson G, Angerhofer A, Benner S
Med Hypotheses
. 2008 Mar;
71(1):22-31.
PMID: 18331782
Humans have relatively low plasma ascorbate levels and high serum uric acid levels compared to most mammals due to the presence of genetic mutations in l-gulonolactone oxidase and uricase, respectively....
8.
Roncal C, Mu W, Reungjui S, Kim K, Henderson G, Ouyang X, et al.
Am J Physiol Renal Physiol
. 2007 Aug;
293(4):F1391-6.
PMID: 17715263
Chronic lead exposure has been epidemiologically linked with hypertension and renal disease. Clinical studies suggest that low lead levels may contribute to renal progression. However, experimental studies have not examined...
9.
Jia M, Coats B, Chadha M, Frentzen B, Perez-Rodriguez J, Chadik P, et al.
J Clin Pharmacol
. 2006 Nov;
46(12):1449-59.
PMID: 17101744
Dichloroacetate (DCA) is a putative environmental hazard, owing to its ubiquitous presence in the biosphere and its association with animal and human toxicity. We sought to determine the kinetics of...
10.
Zolodz M, Jia M, Liu H, Henderson G, Stacpoole P
J Chromatogr B Analyt Technol Biomed Life Sci
. 2006 May;
837(1-2):125-32.
PMID: 16713404
We developed a sensitive method to quantitate the tyrosine metabolites maleylacetone (MA) and succinylacetone (SA) and the tyrosine metabolism inhibitor dichloroacetate (DCA) in biological specimens. Accumulation of these metabolites may...