Peter van Galen
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Explore the profile of Peter van Galen including associated specialties, affiliations and a list of published articles.
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47
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3560
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Recent Articles
1.
Good J, Safina K, Miller T, van Galen P
STAR Protoc
. 2025 Jan;
6(1):103564.
PMID: 39817913
Single-cell RNA sequencing (scRNA-seq) enables detailed characterization of cell states but often lacks insights into tissue clonal structures. Here, we present a protocol to probe cell states and clonal information...
2.
Parsons A, Colon E, Spasic M, Kurt B, Swarbrick A, Freedman R, et al.
Res Sq
. 2024 Nov;
PMID: 39483921
Aging is associated with increased breast cancer risk and outcomes are worse for the oldest and youngest patients, regardless of subtype. It is not known how cells in the breast...
3.
Safina K, van Galen P
Blood
. 2024 Jul;
144(10):1039-1047.
PMID: 38985829
Recent advancements in single-cell genomics have enriched our understanding of hematopoiesis, providing intricate details about hematopoietic stem cell biology, differentiation, and lineage commitment. Technological advancements have highlighted extensive heterogeneity of...
4.
Talvard-Balland N, Braun L, Dixon K, Zwick M, Engel H, Hartmann A, et al.
J Clin Invest
. 2024 Jun;
134(16).
PMID: 38916965
Leukemia relapse is a major cause of death after allogeneic hematopoietic cell transplantation (allo-HCT). We tested the potential of targeting T cell (Tc) immunoglobulin and mucin-containing molecule 3 (TIM-3) for...
5.
Luo Q, Raulston E, Prado M, Wu X, Gritsman K, Whalen K, et al.
Nature
. 2024 May;
630(8015):198-205.
PMID: 38720074
Phosphoinositide-3-kinase-γ (PI3Kγ) is implicated as a target to repolarize tumour-associated macrophages and promote antitumour immune responses in solid cancers. However, cancer cell-intrinsic roles of PI3Kγ are unclear. Here, by integrating...
6.
Heimlich J, Bhat P, Parker A, Jenkins M, Vlasschaert C, Ulloa J, et al.
Blood Adv
. 2024 Mar;
8(14):3665-3678.
PMID: 38507736
Clonal hematopoiesis (CH) is an age-associated phenomenon that increases the risk of hematologic malignancy and cardiovascular disease. CH is thought to enhance disease risk through inflammation in the peripheral blood.1...
7.
Spasic M, Ogayo E, Parsons A, Mittendorf E, van Galen P, McAllister S
Cancer Res Commun
. 2024 Mar;
4(3):895-910.
PMID: 38466569
Significance: This study introduces optimized methods and analysis algorithms that enhance capabilities in comprehensive immunophenotyping of human blood and bone marrow using spectral flow cytometry. This approach facilitates detection of...
8.
Luo Q, Raulston E, Prado M, Wu X, Gritsman K, Yan K, et al.
bioRxiv
. 2024 Feb;
PMID: 38328043
Phosphoinositide 3-kinase gamma (PI3Kγ) is implicated as a target to repolarize tumor-associated macrophages and promote anti-tumor immune responses in solid cancers. However, cancer cell-intrinsic roles of PI3Kγ are unclear. Here,...
9.
Weng C, Yu F, Yang D, Poeschla M, Liggett L, Jones M, et al.
Nature
. 2024 Jan;
627(8003):389-398.
PMID: 38253266
The human blood system is maintained through the differentiation and massive amplification of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this process underlie diverse diseases, but...
10.
Griffin G, Booth C, Togami K, Chung S, Ssozi D, Verga J, et al.
Nature
. 2023 Jun;
618(7966):834-841.
PMID: 37286599
Tumours most often arise from progression of precursor clones within a single anatomical niche. In the bone marrow, clonal progenitors can undergo malignant transformation to acute leukaemia, or differentiate into...