Peter V Kharchenko
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Explore the profile of Peter V Kharchenko including associated specialties, affiliations and a list of published articles.
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96
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13627
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Recent Articles
1.
Embaie B, Sarkar H, Alchahin A, Alchahin A, Otte J, Olsen T, et al.
Cancer Res
. 2025 Jan;
85(6):1015-1034.
PMID: 39808065
Transgenic mice and organoid models, such as three-dimensional tumoroid cultures, have emerged as powerful tools for investigating cancer development and targeted therapies. Yet, the extent to which these preclinical models...
2.
Keller M, Gold I, McCallum C, Manz T, Kharchenko P, Gehlenborg N
Nat Methods
. 2024 Sep;
22(1):63-67.
PMID: 39333268
Multiomics technologies with single-cell and spatial resolution make it possible to measure thousands of features across millions of cells. However, visual analysis of high-dimensional transcriptomic, proteomic, genome-mapped and imaging data...
3.
Mitchel J, Gordon M, Perez R, Biederstedt E, Bueno R, Ye C, et al.
Nat Biotechnol
. 2024 Sep;
PMID: 39313646
Tissue-level and organism-level biological processes often involve the coordinated action of multiple distinct cell types. The recent application of single-cell assays to many individuals should enable the study of how...
4.
Olsen T, Otte J, Mei S, Embaie B, Kameneva P, Cheng H, et al.
Mol Cancer
. 2024 Aug;
23(1):180.
PMID: 39217332
Background: Neuroblastoma (NB) is a heterogeneous embryonal malignancy and the deadliest tumor of infancy. It is a complex disease that can result in diverse clinical outcomes. In some children, tumors...
5.
Kalhor K, Chen C, Lee H, Cai M, Nafisi M, Que R, et al.
Nat Commun
. 2024 Mar;
15(1):2511.
PMID: 38509069
In situ transcriptomic techniques promise a holistic view of tissue organization and cell-cell interactions. There has been a surge of multiplexed RNA in situ mapping techniques but their application to...
6.
Mei S, Alchahin A, Embaie B, Gavriliuc I, Verhoeven B, Zhao T, et al.
JCI Insight
. 2024 Feb;
9(6).
PMID: 38358826
Neuroblastoma is an aggressive pediatric cancer with a high rate of metastasis to the BM. Despite intensive treatments including high-dose chemotherapy, the overall survival rate for children with metastatic neuroblastoma...
7.
Mei S, Alchahin A, Tsea I, Kfoury Y, Hirz T, Jeffries N, et al.
Genome Med
. 2024 Jan;
16(1):1.
PMID: 38281962
Background: Despite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of patients with advanced clear cell renal cell...
8.
Zhang Y, Petukhov V, Biederstedt E, Que R, Zhang K, Kharchenko P
Genome Biol
. 2024 Jan;
25(1):35.
PMID: 38273415
Targeted spatial transcriptomics hold particular promise in analyzing complex tissues. Most such methods, however, measure only a limited panel of transcripts, which need to be selected in advance to inform...
9.
Gao T, Kastriti M, Ljungstrom V, Heinzel A, Tischler A, Oberbauer R, et al.
Nat Genet
. 2023 Oct;
55(11):1901-1911.
PMID: 37904053
Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic single-nucleotide variants have been well characterized in the human body, the patterns and consequences of large chromosomal alterations...
10.
Kalhor K, Chen C, Lee H, Cai M, Nafisi M, Que R, et al.
bioRxiv
. 2023 Aug;
PMID: 37645998
In situ transcriptomic techniques promise a holistic view of tissue organization and cell-cell interactions. Recently there has been a surge of multiplexed RNA in situ techniques but their application to...