Peter V Kharchenko
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Explore the profile of Peter V Kharchenko including associated specialties, affiliations and a list of published articles.
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96
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Recent Articles
11.
Lake B, Menon R, Winfree S, Hu Q, Ferreira R, Kalhor K, et al.
Nature
. 2023 Jul;
619(7970):585-594.
PMID: 37468583
Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods. Here we applied multiple single-cell and single-nucleus assays...
12.
Zhang Y, Petukhov V, Biederstedt E, Que R, Zhang K, Kharchenko P
bioRxiv
. 2023 Mar;
PMID: 36993340
Targeted spatial transcriptomics hold particular promise in analysis of complex tissues. Most such methods, however, measure only a limited panel of transcripts, which need to be selected in advance to...
13.
Hirz T, Mei S, Sarkar H, Kfoury Y, Wu S, Verhoeven B, et al.
Nat Commun
. 2023 Feb;
14(1):663.
PMID: 36750562
The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery, radiation therapy, and hormonal therapy. Recurrence and development of metastatic disease...
14.
Huebner A, Gorelov R, Deviatiiarov R, Demharter S, Kull T, Walsh R, et al.
Nat Cell Biol
. 2023 Jan;
25(3):390-403.
PMID: 36717627
The glandular stomach is composed of two regenerative compartments termed corpus and antrum, and our understanding of the transcriptional networks that maintain these tissues is incomplete. Here we show that...
15.
Haase C, Gustafsson K, Mei S, Yeh S, Richter D, Milosevic J, et al.
Nat Methods
. 2022 Nov;
19(12):1622-1633.
PMID: 36424441
Tissue function depends on cellular organization. While the properties of individual cells are increasingly being deciphered using powerful single-cell sequencing technologies, understanding their spatial organization and temporal evolution remains a...
16.
Faure L, Soldatov R, Kharchenko P, Adameyko I
Bioinformatics
. 2022 Nov;
39(1).
PMID: 36394263
Summary: scFates provides an extensive toolset for the analysis of dynamic trajectories comprising tree learning, feature association testing, branch differential expression and with a focus on cell biasing and fate...
17.
Batiuk M, Tyler T, Dragicevic K, Mei S, Rydbirk R, Petukhov V, et al.
Sci Adv
. 2022 Oct;
8(41):eabn8367.
PMID: 36223459
Schizophrenia is one of the most widespread and complex mental disorders. To characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing (snRNA-seq) of >220,000 neurons from the dorsolateral prefrontal...
18.
Alchahin A, Mei S, Tsea I, Hirz T, Kfoury Y, Dahl D, et al.
Nat Commun
. 2022 Sep;
13(1):5747.
PMID: 36180422
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults. When ccRCC is localized to the kidney, surgical resection or ablation of the tumor...
19.
Gao T, Soldatov R, Sarkar H, Kurkiewicz A, Biederstedt E, Loh P, et al.
Nat Biotechnol
. 2022 Sep;
41(3):417-426.
PMID: 36163550
Genome instability and aberrant alterations of transcriptional programs both play important roles in cancer. Single-cell RNA sequencing (scRNA-seq) has the potential to investigate both genetic and nongenetic sources of tumor...
20.
Verhoeven B, Mei S, Olsen T, Gustafsson K, Valind A, Lindstrom A, et al.
Cell Rep Med
. 2022 Jun;
3(6):100657.
PMID: 35688160
Understanding the complete immune cell composition of human neuroblastoma (NB) is crucial for the development of immunotherapeutics. Here, we perform single-cell RNA sequencing (scRNA-seq) on 19 human NB samples coupled...