Neville E Sanjana
Overview
Explore the profile of Neville E Sanjana including associated specialties, affiliations and a list of published articles.
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77
Citations
12730
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Recent Articles
1.
Caragine C, Le V, Mustafa M, Diaz B, Morris J, Muller S, et al.
Nat Commun
. 2025 Feb;
16(1):1611.
PMID: 39948336
Cis-regulatory elements (CREs), such as enhancers and promoters, are fundamental regulators of gene expression and, across different cell types, the MYC locus utilizes a diverse regulatory architecture driven by multiple...
2.
Hart S, Muller S, Wessels H, Mendez-Mancilla A, Drabavicius G, Choi O, et al.
Nat Biotechnol
. 2025 Feb;
PMID: 39934271
The possibility of collateral RNA degradation poses a concern for transcriptome perturbations and therapeutic applications using CRISPR-Cas13. We show that collateral activity only occurs with high RfxCas13d expression. Using low-copy...
3.
Xue X, Gajic Z, Caragine C, Legut M, Walker C, Kim J, et al.
bioRxiv
. 2024 Dec;
PMID: 39651170
Recent massively-parallel approaches to decipher gene regulatory circuits have focused on the discovery of either -regulatory elements (CREs) or -acting factors. Here, we develop a scalable approach that pairs -...
4.
Yan R, Corman A, Katgara L, Wang X, Xue X, Gajic Z, et al.
Nat Biotechnol
. 2024 Nov;
PMID: 39572737
Pooled single-cell CRISPR screens have profiled either gene expression or chromatin accessibility but not both modalities. Here we develop MultiPerturb-seq, a high-throughput CRISPR screening platform with joint single-nucleus chromatin accessibility,...
5.
Liang W, Muller S, Hart S, Wessels H, Mendez-Mancilla A, Sookdeo A, et al.
Cell
. 2024 Nov;
187(26):7637-7654.e29.
PMID: 39532094
Mammalian genomes host a diverse array of RNA that includes protein-coding and noncoding transcripts. However, the functional roles of most long noncoding RNAs (lncRNAs) remain elusive. Using RNA-targeting CRISPR-Cas13 screens,...
6.
Megagiannis P, Mei Y, Yan R, Yuan L, Wilde J, Eckersberg H, et al.
Cell Rep
. 2024 Aug;
43(8):114637.
PMID: 39154337
Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand brain pathophysiology and improve outcomes....
7.
Hart S, Wessels H, Mendez-Mancilla A, Muller S, Drabavicius G, Choi O, et al.
bioRxiv
. 2024 May;
PMID: 38798586
While CRISPR-Cas13 systems excel in accurately targeting RNA, the potential for collateral RNA degradation poses a concern for therapeutic applications and limits broader adoption for transcriptome perturbations. We evaluate the...
8.
Ferrarone J, Thomas J, Unni A, Zheng Y, Nagiec M, Gardner E, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(21):e2403685121.
PMID: 38743625
The tumor suppressor LKB1 is a serine/threonine protein kinase that is frequently mutated in human lung adenocarcinoma (LUAD). LKB1 regulates a complex signaling network that is known to control cell...
9.
Chen G, Nair G, Osorio A, Holley S, Ghassemzadeh K, Gonzalez J, et al.
bioRxiv
. 2024 Apr;
PMID: 38559217
Autism Spectrum Disorder (ASD) is a highly heritable condition with diverse clinical presentations. Approximately 20% of ASD's genetic susceptibility is imparted by mutations of major effect, most of which cause...
10.
Domingo J, Minaeva M, Morris J, Ghatan S, Ziosi M, Sanjana N, et al.
bioRxiv
. 2024 Mar;
PMID: 38464330
Genomic loci associated with common traits and diseases are typically non-coding and likely impact gene expression, sometimes coinciding with rare loss-of-function variants in the target gene. However, our understanding of...